ArticleAmerican journal of translational research2021
Diagnostic value of miR-153 and miR-203 in patients with cervical cancer and their correlation with human papillomavirus infection.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA.Current medicinal chemistry · 2025Pooled it
- Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches.Infectious agents and cancer · 2025Review
- Article
- Identification of key genes associated with cervical cancer based on bioinformatics analysis.BMC cancer · 2024Article
- Hsa-miR-194-5p and hsa-miR-195-5p are down-regulated expressed in high dysplasia HPV-positive Pap smear samples compared to normal cytology HPV-positive Pap smear samples.BMC infectious diseases · 2024Article
- CREB1 activation promotes human papillomavirus oncogene expression and cervical cancer cell transformation.Journal of medical virology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the diagnostic value of miR-153 and miR-203 in patients with cervical cancer (CC).
methodsA total of 136 CC and suspected CC patients admitted to our hospital were enrolled in this prospective study. Among them, 80 cases had CC, 56 cases with cervical intraepithelial neoplasia, and 40 cases with cervicitis. The normal cervical tissues of the above 176 patients were taken as a control and the expression levels of miR-153, miR-203 and human papillomavirus (HPV) DNA in CC tissues were detected.
resultsThe relative expressions of miR-153 and miR-203 in the CC group were significantly lower than those in the cervicitis and cervical intraepithelial neoplasia groups (all P<0.01). The area under the ROC curve of miR-153 for the diagnosis of CC was 0.883 (95% CI: 0.828-0.938, P<0.001). When the cut-off value of miR-153 expression level in the diagnosis of CC was 0.27, its Youden index, specificity, and sensitivity were 0.748, 0.863, and 0.885, respectively. The area under the ROC curve of miR-203 for the diagnosis of CC was 0.752 (95% CI: 0.680-0.825, P<0.001). When the cut-off value of miR-203 expression level in the diagnosis of CC was 0.51, its Youden index, specificity, and sensitivity were 0.478, 0.615, and 0.863, respectively. Compared with the cervical intraepithelial neoplasia group, HPV infection rate in the CC group was significantly higher (P<0.001). The relative expression levels of miR-153 and miR-203 in HPV-positive patients were significantly lower than those in HPV-negative patients (P<0.001). Significantly lower levels of miR-153 and miR-203 were found in patients with myometrial infiltration, FIGO III-IV stage, and lymphatic metastasis (P<0.05).
conclusionThe expressions of miR-152 and miR-203 are down-regulated in patients with CC, which has diagnostic value for CC. The expressions of miR-153 and miR-203 are correlated with HPV infection and aggressiveness of tumor.
Indexed as
Identifiers
34540103PMC8430153W3201202073What OpenQuestion holds
Registered trials
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