ArticleAmerican journal of translational research2021
Effect of recombinant human basic fibroblast growth factor combined with local application of insulin on pain and healing in diabetic patients with deep II degree burns.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Combined negative pressure wound therapy with new wound dressings to repair a ruptured giant omphalocele in a neonate: a case report and literature review.BMC pediatrics · 2025Review
- Clinical Study of Rh-bFGF Combined With Collagen Sponge in the Treatment of Maxillofacial Deep Ⅱ Degree Burn.The Journal of craniofacial surgery · 2024Article
- An Overview of Recent Developments in the Management of Burn Injuries.International journal of molecular sciences · 2023Review
- Effects of vitamin C combined with rbFGF on inflammatory factors and oxygen environment in patients with high-voltage electrical burns.International wound journal · 2023Article
- Application of recombinant human basic fibroblast growth factor in repair of the aged dog bite wound.Heliyon · 2022Article
- Effect of Combining Immersion Therapy with Shengji Ointment on Wound Healing Rate and Adverse Reaction Rate in Patients with Second-Degree Burn.Journal of healthcare engineering · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the efficacy of recombinant human basic fibroblast growth factor (rh-bFGF) combined with local application of insulin (INS) in diabetic patients with deep II degree burns, and to analyze the changes in pain and healing.
methodsSeventy-eight diabetic patients with deep II degree burns treated in our hospital were divided into the observation group (n=39) for combination therapy of rh-bFGF and local INS, and the control group (n=39) for rh-bFGF alone. The two groups were compared regarding treatment effect, wound healing time, pain degree (Visual Analogue Scale, VAS), wound exudate rate, vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α), as well as adverse reactions.
resultsCompared with the control group, the total clinical effective rate was evidently higher in the observation group (P<0.05). The wound healing time was shorter and the VAS score was lower in the observation group as compared to the control group (both P<0.05). The observation group showed significantly lower wound exudate rate and higher HIF-1α and VEGF protein levels in wound tissue than the control group (all P<0.05). No adverse reactions such as abnormalities in blood routine and hepatorenal function were observed in the two groups during treatment.
conclusionsrh-bFGF combined with local application of INS is markedly effective in diabetic patients with deep II degree burns. It can relieve pain and shorten healing time, with low wound exudate rate and high safety profile.
Indexed as
Identifiers
34540054PMC8430203W3201546633What OpenQuestion holds
Registered trials
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