Evidence map›Paper›PMID 34540013›Full record

ArticleAmerican journal of translational research2021

Efficacy and safety of neoadjuvant chemoradiotherapy plus apatinib for patients with locally advanced, HER2-negative, Siewert's type II-III adenocarcinoma of esophagogastric junction: a single-arm, open-label, phase II trial.

Honghai Guo, Yong Li, Chi Lin, Yunjie Cheng, Zhidong Zhang, Dong Wang, Xuefeng Zhao, Yu Liu, Shaowu Jing, Peigang Yang and 4 more

Abstract read
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Honghai GuoDepartment of Gastrointestinal Surgery, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Yong LiDepartment of Gastrointestinal Surgery, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Chi LinDepartment of Radiation Oncology, University of Nebraska Medical Center Omaha, Nebraska, USA.
Yunjie ChengDepartment of Radiation Oncology, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Zhidong ZhangDepartment of Gastrointestinal Surgery, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Dong WangDepartment of Gastrointestinal Surgery, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Xuefeng ZhaoDepartment of Gastrointestinal Surgery, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Yu LiuDepartment of Gastrointestinal Surgery, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Shaowu JingDepartment of Radiation Oncology, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Peigang YangDepartment of Gastrointestinal Surgery, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Yuan TianDepartment of Gastrointestinal Surgery, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Yang LiuDepartment of Gastrointestinal Surgery, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Jun WangDepartment of Radiation Oncology, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Qun ZhaoDepartment of Gastrointestinal Surgery, Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the efficacy and safety of concurrent neoadjuvant chemoradiotherapy (CRT) plus apatinib in treating locally advanced, HER2-negative, Siewert's type II-III adenocarcinoma of esophagogastric junction (AEG) patients. Thirty eligible patients were analyzed in this single-arm, open-label, phase II trial. Patients received neoadjuvant regimen as follows: two cycles of apatinib (orally, 250 mg/day on day 1-28), two cycles of capecitabine (orally, 1,000 mg/m

Indexed as

adenocarcinoma of esophagogastric junctionapatinibefficacyNeoadjuvant chemoradiotherapysafety

Identifiers

PMID34540013
PMCPMC8430131

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.