Evidence map›Paper›PMID 34539971›Full record

ArticleOxidative medicine and cellular longevity2021

Protective Effects and Mechanisms of Recombinant Human Glutathione Peroxidase 4 on Isoproterenol-Induced Myocardial Ischemia Injury.

Chang Liu, Bozhao Li, Qi Yan, Shaopeng Niu, Yiding Zhao, Changhao Xiong, Tianjiao Zhang, Jingyan Wei

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Exploring the Cardioprotective Potential ofCardiovascular & hematological disorders drug targets · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Cardioprotective effects ofFrontiers in pharmacology · 2025
    Article
  7. Review
  8. Iron Dysregulation in Cardiovascular Diseases.Reviews in cardiovascular medicine · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Chang LiuCollege of Pharmaceutical Science, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0002-5428-370X
Bozhao LiCollege of Pharmaceutical Science, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0001-6502-4722
Qi YanCollege of Pharmaceutical Science, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0002-3814-0733
Shaopeng NiuCollege of Pharmaceutical Science, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0001-9371-4747
Yiding ZhaoCollege of Agriculture and Environmental Science, University of California Davis, Davis, CA 95616, USA.ORCID https://orcid.org/0000-0001-8116-4880
Changhao XiongCollege of Pharmaceutical Science, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0002-7140-5545
Tianjiao ZhangCollege of Pharmaceutical Science, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0001-8355-9253
Jingyan WeiCollege of Pharmaceutical Science, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0002-5707-5260
Jilin University · CNUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic heart disease (IHD) is a cardiovascular disease with high fatality rate, and its pathogenesis is closely related to oxidative stress. Reactive oxygen species (ROS) in oxidative stress can lead to myocardial ischemia (MI) injury in many ways. Therefore, the application of antioxidants may be an effective way to prevent IHD. In recent years, glutathione peroxidase 4 (GPx4) has received increasing attention due to its antioxidant effect. In a previous study, we used the new chimeric tRNA

Indexed as

AnimalsApoptosisBiomarkersCell LineDisease Models, AnimalElectrocardiographyHumansIsoproterenolMaleMembrane Potential, MitochondrialMyocardial InfarctionMyocytes, CardiacOxidative StressPhospholipid Hydroperoxide Glutathione PeroxidaseProtective AgentsRatsBiomarkersIsoproterenolPhospholipid Hydroperoxide Glutathione PeroxidaseProtective AgentsReactive Oxygen SpeciesRecombinant ProteinsTroponin T

Identifiers

PMID34539971
PMCPMC8443360
OpenAlexW3197123922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.