Evidence map›Paper›PMID 34539881›Full record

ArticleJournal of Cancer2021

Bioactive Hexapeptide Reduced the Resistance of Ovarian Cancer Cells to DDP by Affecting HSF1/HSP70 Signaling Pathway.

Ruowen Guo, Qia Xu, Liwei Liu, Hui Liu, Yun Liu, Wenmei Wei, Yide Qin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Bioactive milk peptides: an updated comprehensive overview and database.Critical reviews in food science and nutrition · 2024
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ruowen GuoSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Qia XuSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Liwei LiuSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Hui LiuSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Yun LiuSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Wenmei WeiSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Yide QinSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer is the leading cause of death in gynecologic malignancies. Ovarian cancer as a metastatic malignant tumor is highly recurrent and prone to drug resistance. Bioactive peptides are an emerging area of biomedical research in reducing resistance of tumor cell to drugs. In this paper, we investigated the effects and mechanisms of bioactive hexapeptide (PGPIPN) derived in milk protein on the sensitivity of ovarian cancer cells to cis-dichlorodiammine platinum (DDP). Human ovarian cancer cell lines (SKOV3 and COC1), their DDP-resistant sublines (SKOV3/DDP and COC1/DDP) and human primary ovarian cancer cells were cultured

Indexed as

apoptosisbioactive hexapeptidecell cycledrug resistancehuman ovarian cancersignaling pathway

Identifiers

PMID34539881
PMCPMC8425193
OpenAlexW3198626221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.