Evidence map›Paper›PMID 34539819›Full record

ArticleJournal of drug delivery science and technology2021

Delineating a potent antiviral activity of

Dina B Mahmoud, Walaa M Ismail, Yassmin Moatasim, Omnia Kutkat, Aliaa N ElMeshad, Shahira M Ezzat, Kadriya S El Deeb, Ahlam M El-Fishawy, Mokhtar R Gomaa, Ahmed Kandeil and 3 more

Abstract read
In one paragraph

Article in Journal of drug delivery science and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Biological evaluation, docking studies, andJournal of enzyme inhibition and medicinal chemistry · 2023
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  9. Design and synthesis of novel rigid dibenzo[Journal of enzyme inhibition and medicinal chemistry · 2023
    Article
  10. The GenusInternational journal of molecular sciences · 2023
    Review
  11. Article
  12. ACS omega · 2022
    Article
  13. Thieno[2,3-ACS omega · 2022
    Article
  14. Ligand-based design and synthesis ofJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  15. Ligand-based design, synthesis, computational insights, andJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  16. Article
  17. Anticoagulants as Potential SARS-CoV-2 MInternational journal of molecular sciences · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dina B MahmoudDepartment of Pharmaceutics, Egyptian Drug Authority, formerly known as National Organization for Drug Control and Research, Giza, Egypt.
Walaa M IsmailDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr-El-Ainy Street, Cairo, 11562, Egypt.
Yassmin MoatasimCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
Omnia KutkatCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
Aliaa N ElMeshadDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr-El-Ainy Street, Cairo, 11562, Egypt.
Shahira M EzzatDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr-El-Ainy Street, Cairo, 11562, Egypt.
Kadriya S El DeebDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr-El-Ainy Street, Cairo, 11562, Egypt.
Ahlam M El-FishawyDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr-El-Ainy Street, Cairo, 11562, Egypt.
Mokhtar R GomaaCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
Ahmed KandeilCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt.
Mohamed A AliCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
Ahmed MostafaCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The outbreak of coronavirus disease-2019, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a worldwide emerging crisis. Polyphenols are a class of herbal metabolites with a broad-spectrum antiviral activity. However, most polyphenols encounter limited efficacy due to their poor solubility and degradation in neutral and basic environments. Thus, the effectiveness of their pharmaceutical application is critically dependent on the delivery systems to overcome the aforementioned drawbacks. Herein, Polyphenols-rich

Indexed as

AntiviralCovid-19Cuphea igneaMolecular dockingNanoemulsionPolyphenolsSARS-CoV-2

Identifiers

PMID34539819
PMCPMC8440321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.