Evidence map›Paper›PMID 34539781›Full record

ArticleJournal of oncology2021

Neutrophil-to-Lymphocyte Ratio (NLR) and Monocyte-to-Lymphocyte Ratio (MLR) Predict Clinical Outcome in Patients with Stage IIB Cervical Cancer.

Yong-Xia Li, Jian-Ying Chang, Ming-Yuan He, He-Ran Wang, Dai-Qin Luo, Feng-Hu Li, Jie-Hui Li, Li Ran

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Article in Journal of oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  4. Diagnostic and prognostic role of NLR in testicular cancer.Exploration of targeted anti-tumor therapy · 2024
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  5. Cancer risk and mortality assessment in the overweight population: evaluation of single and integrated models based on inflammatory markers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yong-Xia LiDepartment of Oncology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.ORCID https://orcid.org/0000-0002-6445-9705
Jian-Ying ChangDepartment of Oncology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Ming-Yuan HeDepartment of Oncology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
He-Ran WangDepartment of Breast Oncology, Guizhou Cancer Hospital, Guiyang, Guizhou Province, China.
Dai-Qin LuoDepartment of Oncology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Feng-Hu LiDepartment of Oncology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Jie-Hui LiDepartment of Oncology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Li RanDepartment of Breast Oncology, Guizhou Cancer Hospital, Guiyang, Guizhou Province, China.ORCID https://orcid.org/0000-0002-8795-0150

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionStage IIB cervical cancer (CC) is an advanced stage CC with poor prognosis. Inflammatory response plays a crucial role in the development of CC, and systemic inflammatory indexes were related to the prognosis in several cancers. The objective of the study was to determine the prognostic value of platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR), and systemic inflammation response index (SIRI) as inflammatory indexes in patients with stage IIB CC. MATERIALS AND

methodsA retrospective study was performed in 260 patients with stage IIB CC. PLR, NLR, MLR, BLR, and SIRI were obtained from routine blood tests. Prognosis information of the patients was acquired from regular clinical follow-up. Recurrence and response to therapy were determined through electronic medical records (EMRs). Correlations of the inflammatory indexes with overall survival (OS), progression-free survival (PFS), recurrence, and response to therapy were analyzed using SPSS version 26.0 software.

resultsReceiver operating characteristic (ROC) curve analyses suggested that NLR, MLR, and SIRI had better predictive value than PLR as well as BLR in the prognosis and recurrence risk. Both univariate and multivariate survival analyses showed that higher NLR and MLR were significantly associated with shorter OS as well as PFS, whereas SIRI was not an independent predictive factor of PFS. Chi-square test results revealed that increased NLR was significantly correlated with higher recurrence rate (

conclusionsFor patients with stage IIB CC, both NLR and MLR are independent prognostic factors as well as risk factors for recurrence; NLR serves as a potential marker for therapeutic response.

Identifiers

PMID34539781
PMCPMC8443385

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