ArticleNeural plasticity2021
Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder.
Article in Neural plasticity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis.Frontiers in psychiatry · 2024Review
- Neurological activation during verbal fluency task and resting-state functional connectivity abnormalities in obsessive-compulsive disorder: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2024Article
- Altered dynamic neural activities in individuals with obsessive-compulsive disorder and comorbid depressive symptoms.Frontiers in psychiatry · 2024Article
- Shared and Disorder-Specific Alterations of Brain Temporal Dynamics in Obsessive-Compulsive Disorder and Schizophrenia.Schizophrenia bulletin · 2023Article
- Compromised Cerebello-Thalamic White Matter Integrity in Medication-Free Patients With Obsessive-Compulsive Disorder.Psychiatry investigation · 2023Article
- Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder.BMC psychiatry · 2023Article
- Anatomical distance affects functional connectivity at rest in medicine-free obsessive-compulsive disorder.BMC psychiatry · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Background: Previous studies explored the whole-brain functional connectome using the degree approach in patients with obsessive-compulsive disorder (OCD). However, whether the altered degree values can be used to discriminate OCD from healthy controls (HCs) remains unclear. Methods: A total of 40 medication-free patients with OCD and 38 HCs underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Data were analyzed with the degree approach and a support vector machine (SVM) classifier. Results: Patients with OCD showed increased degree values in the left thalamus and left cerebellum Crus I and decreased degree values in the left dorsolateral prefrontal cortex, right precuneus, and left postcentral gyrus. SVM classification analysis indicated that the increased degree value in the left thalamus is a marker of OCD, with an acceptable accuracy of 88.46%, sensitivity of 87.50%, and specificity of 89.47%. Conclusion: Altered degree values within and outside the cortical-striatal-thalamic-cortical (CSTC) circuit may cocontribute to the pathophysiology of OCD. Increased degree values of the left thalamus can be used as a future marker for OCD understanding-classification.
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