Evidence map›Paper›PMID 34539665›Full record

ArticleFrontiers in immunology2021

Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in

Serena Bettoni, Karolina Maziarz, M Rhia L Stone, Mark A T Blaskovich, Jan Potempa, Maria Luiza Bazzo, Magnus Unemo, Sanjay Ram, Anna M Blom

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. C4BP occludes the non-opsonic interaction ofInfection and immunity · 2026
    Article
  2. Article
  3. C4BP occludes the non-opsonic interaction ofbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Research Advances in Fusion Protein-Based Drugs for Diabetes Treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
  9. Diverse Functions of C4b-Binding Protein in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  10. Clinical Isolates ofFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Serena BettoniDepartment of Translational Medicine, Lund University, Malmö, Sweden.
Karolina MaziarzDepartment of Translational Medicine, Lund University, Malmö, Sweden.
M Rhia L StoneCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Mark A T BlaskovichCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Jan PotempaFaculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
Maria Luiza BazzoMolecular Biology, Microbiology and Serology Laboratory, Federal University of Santa Catarina, Florianópolis, Brazil.
Magnus UnemoWorld Health Organization (WHO) Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Örebro University, Örebro, Sweden.
Sanjay RamDepartment of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA, United States.
Anna M BlomDepartment of Translational Medicine, Lund University, Malmö, Sweden.
Lund University · SEUniversity of Queensland · AUJagiellonian University · PLÖrebro University · SEUniversidade Federal de Santa Catarina · BRUniversity of Massachusetts Chan Medical School · US

Funding

An immunotherapeutic to prevent gonorrheaR44AI147930 · NIAID · PLANET BIOTECHNOLOGY, INC. · PI RAM, SANJAY, WYCOFF, KEITH · 2019 to 2021
$2.0M
NIAID NIH HHS R44 AI147930
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Complement ActivationAnti-Bacterial AgentsAzithromycinCiprofloxacinComplement C4b-Binding ProteinDrug Resistance, BacterialHumansImmunoglobulin MNeisseria gonorrhoeaeRecombinant Fusion ProteinsSpectinomycinAnti-Bacterial AgentsAzithromycinCiprofloxacinComplement C4b-Binding ProteinImmunoglobulin MRecombinant Fusion ProteinsSpectinomycinantibiotic resisitanceC4b binding proteincomplementmembrane attack complex (MAC)Neisseria gonorrhoeae

Identifiers

PMID34539665
PMCPMC8440848
OpenAlexW3198669995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.