Evidence map›Paper›PMID 34539660›Full record

ArticleFrontiers in immunology2021

The First Chemically-Synthesised, Highly Immunogenic Anti-SARS-CoV-2 Peptides in DNA Genotyped

Manuel E Patarroyo, Manuel A Patarroyo, Martha P Alba, Laura Pabon, María T Rugeles, Wbeimar Aguilar-Jimenez, Lizdany Florez, Adriana Bermudez, Ashok K Rout, Christian Griesinger and 9 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The role of HLA genotypes in understanding the pathogenesis of severe COVID-19.The Egyptian journal of medical human genetics · 2023
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Manuel E PatarroyoFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Manuel A PatarroyoFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Martha P AlbaFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Laura PabonFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
María T RugelesGrupo Inmunovirología, Universidad de Antioquia, Medellín, Colombia.
Wbeimar Aguilar-JimenezGrupo Inmunovirología, Universidad de Antioquia, Medellín, Colombia.
Lizdany FlorezGrupo Inmunovirología, Universidad de Antioquia, Medellín, Colombia.
Adriana BermudezFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Ashok K RoutDepartment of NMR Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Christian GriesingerDepartment of NMR Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Carlos F SuarezFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Jorge Aza-CondeFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
César ReyesFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Catalina AvendañoFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Jhoan SamacáFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Anny CamargoFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Yolanda SilvaFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Martha ForeroFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Edgardo GonzalezFundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thirty-five peptides selected from functionally-relevant SARS-CoV-2 spike (S), membrane (M), and envelope (E) proteins were suitably modified for immunising MHC class II (MHCII) DNA-genotyped

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralAotidaeCoronavirus Envelope ProteinsCoronavirus M ProteinsCOVID-19COVID-19 VaccinesHLA-DRB1 ChainsHumansPeptidesSARS-CoV-2Spike Glycoprotein, CoronavirusVaccines, SubunitAntibodies, NeutralizingAntibodies, ViralCoronavirus Envelope ProteinsCoronavirus M ProteinsCOVID-19 Vaccinesenvelope protein, SARS-CoV-2HLA-DRB1 ChainsM protein, SARS-CoVPeptidesSpike Glycoprotein, Coronavirusspike glycoprotein, SARS-CoVVaccines, SubunitHLA-DRβ1*/Aona-DRβimmune responseMHCII-peptide-TCR complexmodified synthetic peptideneutralising antibodyPPIIL-propensitySARS-CoV-2

Identifiers

PMID34539660
PMCPMC8446425

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.