Evidence map›Paper›PMID 34539659›Full record

ArticleFrontiers in immunology2021

Immunological Adverse Events After Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis Patients.

Patrick-Pascal Strunz, Matthias Froehlich, Michael Gernert, Eva Christina Schwaneck, Anna Fleischer, Ann-Christin Pecher, Hans-Peter Tony, Joerg Christoph Henes, Marc Schmalzing

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Stem cell therapy in systemic sclerosis.Clinical rheumatology · 2025
    Review
  3. Article
  4. [Paraneoplastic syndromes in rheumatology].Zeitschrift fur Rheumatologie · 2023
    Review
  5. Stem cell-based therapy for systemic sclerosis.Rheumatology advances in practice · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Patrick-Pascal StrunzDepartment of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.
Matthias FroehlichDepartment of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.
Michael GernertDepartment of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.
Eva Christina SchwaneckDepartment of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.
Anna FleischerDepartment of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.
Ann-Christin PecherDepartment of Internal Medicine II, University Hospital of Tuebingen, Tuebingen, Germany.
Hans-Peter TonyDepartment of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.
Joerg Christoph HenesDepartment of Internal Medicine II, University Hospital of Tuebingen, Tuebingen, Germany.
Marc SchmalzingDepartment of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.
Universitätsklinikum Würzburg · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous hematopoietic stem cell transplantation (aHSCT) represents an effective treatment for systemic sclerosis (SSc), but it also can cause immunological adverse events (iAEs). Therefore, we aimed to determine the frequency of iAEs [engraftment syndrome (ES) and secondary autoimmune disorder (sAD)] and to identify potential risk factors for their development in a retrospective analysis on 22 patients similarly transplanted due to SSc. While nine patients (41%) suffered from ESs, seven sADs occurred in six patients (27%). Patients who developed ES were older in our cohort (52.45

Indexed as

AdultAutoimmune DiseasesFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedRetrospective StudiesRisk FactorsScleroderma, SystemicSyndromeTransplantation, AutologousTreatment OutcomeYoung Adultautoimmune diseaseengraftment syndromefeverGrave’s diseasemodified Rodnan skin score (mRSS)risk factor analysissclerodermaSjögren’s syndrome

Identifiers

PMID34539659
PMCPMC8447845
OpenAlexW3196829326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.