Evidence map›Paper›PMID 34539651›Full record

ArticleFrontiers in immunology2021

Augmented Expansion of Treg Cells From Healthy and Autoimmune Subjects

James L Reading, Valerie D Roobrouck, Caroline M Hull, Pablo Daniel Becker, Jelle Beyens, Alice Valentin-Torres, Dominic Boardman, Estefania Nova Lamperti, Samantha Stubblefield, Giovanna Lombardi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

James L ReadingCancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, United Kingdom.
Valerie D RoobrouckDepartment of R&D, ReGenesys BV, Leuven, Belgium.
Caroline M HullPeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Pablo Daniel BeckerKing's College London Department of Immunoregulation and Immune Intervention, Guy's Hospital, London, United Kingdom.
Jelle BeyensDepartment of R&D, ReGenesys BV, Leuven, Belgium.
Alice Valentin-TorresDepartment of R&D, Athersys Inc., Cleveland, OH, United States.
Dominic BoardmanDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.
Estefania Nova LampertiMolecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepcion, Concepcion, Chile.
Samantha StubblefieldDepartment of R&D, Athersys Inc., Cleveland, OH, United States.
Giovanna LombardiMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
Robert DeansDepartment of R&D, ReGenesys BV, Leuven, Belgium.
Anthony E TingDepartment of R&D, Athersys Inc., Cleveland, OH, United States.
Timothy TreePeter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Athersys (United States) · USKing's College London · GBGuy's and St Thomas' NHS Foundation Trust · GBGuy's Hospital · GBUniversity College London · GBUniversity of British Columbia · CAUniversity of Concepción · CL

Funding

British Heart Foundation RG/13/12/30395Department of Health
6 · The paper itself

Abstract

Recent clinical experience has demonstrated that adoptive regulatory T (Treg) cell therapy is a safe and feasible strategy to suppress immunopathology

Indexed as

AutoimmunityLymphocyte CountAdult Stem CellsAnimalsAutoimmune DiseasesBiomarkersCells, CulturedCoculture TechniquesDisease Models, AnimalDisease SusceptibilityFemaleGene Expression RegulationGraft vs Host DiseaseHumansImmunophenotypingMaleBiomarkersadult progenitor cellsautoimmune diseasesco-cultureex vivo expansionregulatory T (Treg) cells

Identifiers

PMID34539651
PMCPMC8442662
OpenAlexW3197600699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.