ArticleFrontiers in immunology2021
Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions.
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Clinical, microbial and metabolic characteristics of gas-forming pyogenic liver abscess and its potential formation mechanism.Frontiers in cellular and infection microbiology · 2026Article
- Assessment of In Vitro Antioxidant Activity and Subacute Toxicity and Safety of Tetrahydroserpentine in Hyperglycemic Mice.Chemistry & biodiversity · 2026Article
- Serum metabolomics identifies biomarkers in radicular cysts.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Decoding immunometabolism with next-generation tools: lessons from dendritic cells and T cells.The EMBO journal · 2025Review
- Metabolite changes in oral tumours and cysts: a narrative review.BMC oral health · 2025Review
- Integrated metagenomics and transcriptomics analysis reveals pathways associated with oral periapical lesions formation and progression.Current research in microbial sciences · 2025Article
- Fractal Dimension Approach for Quantitative Analysis Radiograph in Periapical Inflammation: A Systematic Review.Acta medica Philippina · 2025Article
- Reduction of NrF2 as coadjuvant during the development of persistent periapical lesions.Medicina oral, patologia oral y cirugia bucal · 2023Observational
- Molecular pathogenicity of 1-nonadecene and L-lactic acid, unique metabolites in radicular cysts and periapical granulomas.Scientific reports · 2023Article
- Human Archaeological Dentin as Source of Polar and Less Polar Metabolites for Untargeted Metabolomic Research: The Case ofMetabolites · 2023Article
- Article
- Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: 3-Dimensional Analysis Using Cone-Beam Computed Tomography on the Outcomes of Non-Surgical Endodontic Treatment Using A-PRF+ and Calcium Hydroxide: A Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Phenolic Contents and Antioxidant Activity ofAntioxidants (Basel, Switzerland) · 2022Article
- Estimating the viral loads of SARS-CoV-2 in the oral cavity when complicated with periapical lesions.BMC oral health · 2021Article
- TLR4 expression and its immunopathogenic role in inflammatory radicular cysts: a clinicopathological study.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periapical abscesses, radicular cysts, and periapical granulomas are the most frequently identified pathological lesions in the alveolar bone. While little is known about the initiation and progression of these conditions, the metabolic environment and the related immunological behaviors were examined for the first time to model the development of each pathological condition. Metabolites were extracted from each lesion and profiled using gas chromatography-mass spectrometry in comparison with healthy pulp tissue. The metabolites were clustered and linked to their related immune cell fractions. Clusters I and J in the periapical abscess upregulated the expression of MMP-9, IL-8, CYP4F3, and VEGF, while clusters L and M were related to lipophagy and apoptosis in radicular cyst, and cluster P in periapical granuloma, which contains L-(+)-lactic acid and ethylene glycol, was related to granuloma formation. Oleic acid, 17-octadecynoic acid, 1-nonadecene, and L-(+)-lactic acid were significantly the highest unique metabolites in healthy pulp tissue, periapical abscess, radicular cyst, and periapical granuloma, respectively. The correlated enriched metabolic pathways were identified, and the related active genes were predicted. Glutamatergic synapse (16-20),-hydroxyeicosatetraenoic acids, lipophagy, and retinoid X receptor coupled with vitamin D receptor were the most significantly enriched pathways in healthy control, abscess, cyst, and granuloma, respectively. Compared with the healthy control, significant upregulation in the gene expression of
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