Evidence map›Paper›PMID 34539634›Full record

ArticleFrontiers in immunology2021

Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells.

Natalie Baum, Marie Eggers, Julia Koenigsdorf, Stephan Menzel, Julia Hambach, Tobias Staehler, Ralf Fliegert, Frederike Kulow, Gerhard Adam, Friedrich Haag and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. CD38 as theranostic target in oncology.Journal of translational medicine · 2024
    Review
  3. Article
  4. NADProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. Review
  6. CD38-specific nanobodies allowFrontiers in immunology · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Natalie BaumInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marie EggersInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Julia KoenigsdorfInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stephan MenzelInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Julia HambachInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tobias StaehlerInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ralf FliegertDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Frederike KulowDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Gerhard AdamDepartment of Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Friedrich HaagInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Peter BannasDepartment of Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Friedrich Koch-NolteInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Universität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD38 is the major NAD

Indexed as

Antibody-Dependent Cell CytotoxicityADP-ribosyl Cyclase 1AnimalsAntibodies, Monoclonal, Murine-DerivedAntibodies, NeoplasmCell Line, TumorHumansImmunoglobulin Heavy ChainsMembrane GlycoproteinsMiceMice, Inbred BALB CMice, KnockoutNeoplasmsADP-ribosyl Cyclase 1Antibodies, Monoclonal, Murine-DerivedAntibodies, NeoplasmCD38 protein, humanImmunoglobulin Heavy ChainsMembrane Glycoproteinsantibody-dependent cellular cytotoxicityantibody engineeringCD38complement-dependent cytotoxicityheavy chain antibodymultiple myelomaNAD+nanobody

Identifiers

PMID34539634
PMCPMC8446682
OpenAlexW3197747228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.