Evidence map›Paper›PMID 34539632›Full record

ReviewFrontiers in immunology

Saliva-Based ELISAs for Effective SARS-CoV-2 Antibody Monitoring in Vaccinated Individuals.

Joseph G Casian, Aaron N Angel, Ronell Lopez, Cedie Bagos, Melanie A MacMullan, Mindy L Bui, Prithivi Chellamathu, Sudipta Das, Fred Turner, Vladimir Slepnev and 1 more

Abstract readReview
In one paragraph

Review in Frontiers in immunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joseph G CasianDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.
Aaron N AngelDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.
Ronell LopezDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.
Cedie BagosDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.
Melanie A MacMullanDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.
Mindy L BuiDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.
Prithivi ChellamathuDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.
Sudipta DasDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.
Fred TurnerDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.
Vladimir SlepnevDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.
Albina IbrayevaDepartment of Serology Research and Development, Curative, Monrovia, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In March 2020, the World Health Organization (WHO) declared a global health emergency-the coronavirus disease 2019 (COVID-19) pandemic. Since then, the development and implementation of vaccines against the virus amidst emerging cases of re-infection has prompted researchers to work towards understanding how immunity develops and is sustained. Serological testing has been instrumental in monitoring the development and persistence of antibodies against SARS-CoV-2 infection, however inconsistencies in detection have been reported by different methods. As serological testing becomes more commonplace, it is important to establish widespread and repeatable processes for monitoring vaccine efficacy. Therefore, we present enzyme linked immunosorbent assays (ELISAs) compatible for antibody detection in saliva as highly accurate, efficacious, and scalable tools for studying the immune response in individuals vaccinated against SARS-CoV-2.

Indexed as

Antibodies, NeutralizingAntibodies, ViralCOVID-19COVID-19 VaccinesEnzyme-Linked Immunosorbent AssayHumansSalivaSARS-CoV-2Antibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesdiagnosticELISAsimmunologysaliva-based antibody detectionSARS-CoV-2vaccines

Identifiers

PMID34539632
PMCPMC8446671

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.