Evidence map›Paper›PMID 34539616›Full record

ArticleFrontiers in microbiology2021

Schistosome AMPK Is Required for Larval Viability and Regulates Glycogen Metabolism in Adult Parasites.

Kasandra S Hunter, André Miller, Margaret Mentink-Kane, Stephen J Davies

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Inhibition of AMPK activation inAntimicrobial agents and chemotherapy · 2024
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kasandra S HunterDepartment of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, MD, United States.
André MillerSchistosomiasis Resource Center, Biomedical Research Institute, Rockville, MD, United States.
Margaret Mentink-KaneSchistosomiasis Resource Center, Biomedical Research Institute, Rockville, MD, United States.
Stephen J DaviesDepartment of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, MD, United States.
Biomedical Research Institute · USUniformed Services University of the Health Sciences · US

Funding

NIAID NIH HHS HHSN272201700014C
6 · The paper itself

Abstract

On entering the mammalian host, schistosomes transition from a freshwater environment where resources are scarce, to an environment where there is an unlimited supply of glucose, their preferred energy substrate. Adult schistosome glycolytic activity consumes almost five times the parasite's dry weight in glucose per day to meet the parasite's energy demands, and the schistosome glycolytic enzymes and mechanisms for glucose uptake that sustain this metabolic activity have previously been identified. However, little is known of the parasite processes that regulate schistosome glucose metabolism. We previously described the

Indexed as

5′ AMP-activated protein kinaseAMPK (5′-AMP activated kinase)energy metabolismglycogenglycolysisRNA interferenceSchistosoma mansonischistosome

Identifiers

PMID34539616
PMCPMC8440919
OpenAlexW3198870953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.