Evidence map›Paper›PMID 34539562›Full record

ReviewFrontiers in neurology2021

Blood Pressure Management After Endovascular Thrombectomy.

Teng J Peng, Santiago Ortega-Gutiérrez, Adam de Havenon, Nils H Petersen

Abstract readReview
In one paragraph

Review in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Blood pressure targets after successful reperfusion in mechanical thrombectomy for acute ischemic stroke: an updated systematic review and meta-analysis of randomized clinical trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  5. Trial
  6. Article
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  8. Observational
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  11. Review
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  15. Good outcome associated with blood-brain barrier disruption and lower blood pressure after endovascular therapy.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Teng J PengDepartment of Neurology, Yale University School of Medicine, New Haven, CT, United States.
Santiago Ortega-GutiérrezDepartment of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, United States.
Adam de HavenonDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Nils H PetersenDepartment of Neurology, Yale University School of Medicine, New Haven, CT, United States.

Funding

Precision blood pressure management after endovascular stroke therapy based on real-time autoregulation measurementsK23NS110980 · NINDS · YALE UNIVERSITY · PI PETERSEN, NILS H. · 2020 to 2024
$951k
NINDS NIH HHS K23 NS110980
6 · The paper itself

Abstract

Endovascular thrombectomy (EVT) has changed the landscape of acute stroke therapy and has become the standard of care for selected patients presenting with anterior circulation large-vessel occlusion (LVO) stroke. Despite successful reperfusion, many patients with LVO stroke do not regain functional independence. Particularly, patients presenting with extremes of blood pressure (BP) or hemodynamic variability are found to have a worse clinical recovery, suggesting blood pressure optimization as a potential neuroprotective strategy. Current guidelines acknowledge the lack of randomized trials to evaluate the optimal hemodynamic management during the immediate post-stroke period. Following reperfusion, lower blood pressure targets may be warranted to prevent reperfusion injury and promote penumbral recovery, but adequate BP targets adjusted to individual patient factors such as degree of reperfusion, infarct size, and overall hemodynamic status remain undefined. This narrative review outlines the physiological mechanisms of BP control after EVT and summarizes key observational studies and clinical trials evaluating post-EVT BP targets. It also discusses novel treatment strategies and areas of future research that could aid in the determination of the optimal post-EVT blood pressure.

Indexed as

blood pressurecerebral autoregulationneurocritical carestrokethrombectomy

Identifiers

PMID34539562
PMCPMC8446280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.