Evidence map›Paper›PMID 34539480›Full record

ArticleFrontiers in psychology2021

Loneliness Mediates the Relationship Between Early Life Stress and Perceived Stress but not Hypothalamic-Pituitary-Adrenal Axis Functioning.

Isabel Crespo-Sanmiguel, Mariola Zapater-Fajarí, Matias M Pulopulos, Vanesa Hidalgo, Alicia Salvador

Abstract read
In one paragraph

Article in Frontiers in psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isabel Crespo-SanmiguelLaboratory of Social Cognitive Neuroscience, Psychobiology-IDOCAL, University of Valencia, Valencia, Spain.
Mariola Zapater-FajaríLaboratory of Social Cognitive Neuroscience, Psychobiology-IDOCAL, University of Valencia, Valencia, Spain.
Matias M PulopulosDepartment of Psychology and Sociology, Area of Psychobiology, IIS Aragón, University of Zaragoza, Teruel, Spain.
Vanesa HidalgoDepartment of Psychology and Sociology, Area of Psychobiology, IIS Aragón, University of Zaragoza, Teruel, Spain.
Alicia SalvadorLaboratory of Social Cognitive Neuroscience, Psychobiology-IDOCAL, University of Valencia, Valencia, Spain.

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Social Ties and Health: Aggregating Data from Five Viral-Challenge TrialsR01AT006694 · NCCIH · CARNEGIE-MELLON UNIVERSITY · PI COHEN, SHELDON A · 2011 to 2015
$1.5M
Stress, Cellular Aging and Susceptibility to Infectious DiseaseRC1AT005799 · NCCIH · CARNEGIE-MELLON UNIVERSITY · PI COHEN, SHELDON A · 2009 to 2010
$448k
NCATS NIH HHS UL1 TR000005NCCIH NIH HHS R01 AT006694NCCIH NIH HHS RC1 AT005799NCRR NIH HHS UL1 RR024153
6 · The paper itself

Abstract

Many authors have proposed that early life stress (ELS) provokes a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and contributes negatively to the management of stress in adulthood. However, these associations have not always been observed, making it necessary to include new factors that could explain the different results found. In this regard, people with ELS experiences report less social support during adulthood, suggesting that loneliness could be a mediating factor. Thus, our aims were to investigate whether ELS was related to both perceived stress and diurnal HPA axis activity, and whether loneliness mediates these relationships, in a community sample (

Indexed as

adulthoodearly life stresshypothalamic–pituitary–adrenal axislonelinessperceived stress

Identifiers

PMID34539480
PMCPMC8446206

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.