Evidence map›Paper›PMID 34539472›Full record

ArticleFrontiers in psychiatry2021

Effects of High-Frequency rTMS on Negative Symptoms and Cognitive Function in Hospitalized Patients With Chronic Schizophrenia: A Double-Blind, Sham-Controlled Pilot Trial.

Na Wen, Lei Chen, Xuemeng Miao, Min Zhang, Yaoyao Zhang, Jie Liu, Yao Xu, Siyu Tong, Wei Tang, Mengpu Wang and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  4. The Genoeconomics of Impulsive Intertemporal Choice: A Critical Review.Journal of the experimental analysis of behavior · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Na WenThe Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, China.
Lei ChenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Xuemeng MiaoSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Min ZhangSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Yaoyao ZhangSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Jie LiuSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Yao XuSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Siyu TongSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Wei TangThe Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, China.
Mengpu WangSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Jiahong LiuThe Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, China.
Siyao ZhouSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Xinyu FangAffiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Ke ZhaoSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Wenzhou Medical University · CNJinzhou Kangning Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) over left dorsolateral pre-frontal cortex (DLPFC) in ameliorating negative symptoms and cognitive impairments in patients with chronic schizophrenia. Fifty-two patients with chronic schizophrenia were randomly assigned to two groups: active rTMS group and sham rTMS group, with existing antipsychotic drugs combined 20 sessions of 10 Hz active/sham rTMS over DLPFC (20 min/session, 5 times/week). The PANSS, RBANS, and SCWT were used to evaluate the clinical symptoms and cognitive functions of the patients. Our results indicated significant improvements in clinical symptoms (PANSS total and subscale scores) and cognitive functions (RBANS total and subscale scores, card 1 and card 3 of the SCWT test) (All

Indexed as

cognitive impairmentnegative symptoms (schizophrenia)repetitive transcranial magnetic stimulationschizophreniatreatment

Identifiers

PMID34539472
PMCPMC8446365
OpenAlexW3197633524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.