Evidence map›Paper›PMID 34539446›Full record

ArticleFrontiers in physiology2021

Exploring the Association Between Genetic Polymorphisms in Genes Involved in Craniofacial Development and Isolated Tooth Agenesis.

Erika Calvano Küchler, Caio Luiz Bitencourt Reis, Alice Corrêa Silva-Sousa, Guido Artemio Marañón-Vásquez, Mirian Aiko Nakane Matsumoto, Aline Sebastiani, Rafaela Scariot, Eva Paddenberg, Peter Proff, Christian Kirschneck

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Association between dental age variation and EGF, EGFR, TGFB1, and TGFB2 genetic polymorphisms.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
    Article
  2. Article
  3. Dissecting the Genetic Contribution of Tooth Agenesis.International journal of molecular sciences · 2025
    Review
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  12. The association of polymorphisms inSaudi journal of biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Erika Calvano KüchlerDepartment of Orthodontics, University Medical Centre of Regensburg, Regensburg, Germany.
Caio Luiz Bitencourt ReisDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Alice Corrêa Silva-SousaDepartment of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Guido Artemio Marañón-VásquezDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Mirian Aiko Nakane MatsumotoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Aline SebastianiDepartment of Stomatology, Federal University of Paraná, Curitiba, Brazil.
Rafaela ScariotDepartment of Stomatology, Federal University of Paraná, Curitiba, Brazil.
Eva PaddenbergDepartment of Orthodontics, University Medical Centre of Regensburg, Regensburg, Germany.
Peter ProffDepartment of Orthodontics, University Medical Centre of Regensburg, Regensburg, Germany.
Christian KirschneckDepartment of Orthodontics, University Medical Centre of Regensburg, Regensburg, Germany.
Universidade de São Paulo · BRUniversidade Federal do Paraná · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tooth agenesis is a common congenital anomaly in humans and is more common in oral cleft patients than in the general population. Many previous studies suggested that oral cleft and tooth agenesis share a similar genetic background. Therefore, this study explored the association between isolated tooth agenesis and genetic polymorphisms in genes that are crucial for craniofacial and tooth development. Panoramic radiographs, anamnesis, and genomic DNA from 273 patients were included. Patients were classified as tooth agenesis present, when at least one permanent tooth was congenitally missing. Patients with syndromes and oral cleft were excluded. Only unrelated patients were included. The genetic polymorphisms in

Indexed as

craniofacial developmentdental anomalygenetic polymorphismssingle nucelotide polymorphismstooth agenesis

Identifiers

PMID34539446
PMCPMC8440976
OpenAlexW3196570531

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.