Evidence map›Paper›PMID 34539438›Full record

ArticleFrontiers in physiology2021

Clinically-Driven Virtual Patient Cohorts Generation: An Application to Aorta.

Pau Romero, Miguel Lozano, Francisco Martínez-Gil, Dolors Serra, Rafael Sebastián, Pablo Lamata, Ignacio García-Fernández

Abstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Full-field surrogate modeling of cardiac electrophysiology encoding geometric variability.Computer methods in applied mechanics and engineering · 2026
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  10. 3D cardiac shape analysis with variational point cloud autoencoders for myocardial infarction prediction and virtual heart synthesis.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2025
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  17. A systematic review of cardiacProgress in biomedical engineering (Bristol, England) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pau RomeroComputational Multiscale Simulation Lab, Department of Computer Science, Universitat de Valencia, Valencia, Spain.
Miguel LozanoComputational Multiscale Simulation Lab, Department of Computer Science, Universitat de Valencia, Valencia, Spain.
Francisco Martínez-GilComputational Multiscale Simulation Lab, Department of Computer Science, Universitat de Valencia, Valencia, Spain.
Dolors SerraComputational Multiscale Simulation Lab, Department of Computer Science, Universitat de Valencia, Valencia, Spain.
Rafael SebastiánComputational Multiscale Simulation Lab, Department of Computer Science, Universitat de Valencia, Valencia, Spain.
Pablo LamataDepartment of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, Kings College London, London, United Kingdom.
Ignacio García-FernándezComputational Multiscale Simulation Lab, Department of Computer Science, Universitat de Valencia, Valencia, Spain.

Funding

Wellcome Trust 209450/Z/17/Z
6 · The paper itself

Abstract

The combination of machine learning methods together with computational modeling and simulation of the cardiovascular system brings the possibility of obtaining very valuable information about new therapies or clinical devices through

Indexed as

clinically-driven samplingdigital twingenerative adversarial networkin-silico trialssupport vector machinesynthetic populationthoracic-aortavirtual cohort

Identifiers

PMID34539438
PMCPMC8440937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.