ArticleFrontiers in aging neuroscience2021
Secular Trends in the Incidence of and Mortality Due to Alzheimer's Disease and Other Forms of Dementia in China From 1990 to 2019: An Age-Period-Cohort Study and Joinpoint Analysis.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer's disease: a meta-analysis.GeroScience · 2025Pooled it
- Global Trends and Disparities in Early-Onset Dementia: Systematic Analysis and Projection from the Global Burden of Diseases 2021 Study.Neuroepidemiology · 2026Article
- Thirty-seven-year trends in the prevalence, incidence, and prognosis of dementia in a Japanese community: the Hisayama study.Alzheimer's research & therapy · 2025Article
- Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein.Nutrients · 2025Review
- Trends and inequalities in the global burden of alzheimer's disease and other dementias, 1990-2021: a Chinese perspective.BMC public health · 2025Article
- Burden of risk factors attributable to Alzheimer's disease and other dementia and its relationship with the Socio-Demographic index in Asia.BMC neurology · 2025Article
- Burden of ischemic stroke attributable to high low-density lipoprotein cholesterol in China from the global burden of disease study 2021.Scientific reports · 2025Article
- Global incidence trends and projections of Alzheimer disease and other dementias: an age-period-cohort analysis 2021.Journal of global health · 2025Article
- The disease burden, risk factors and future predictions of Alzheimer's disease and other types of dementia in Asia from 1990 to 2021.The journal of prevention of Alzheimer's disease · 2025Article
- Growth-Associated Protein 43 Levels in the Cerebrospinal Fluid Correspond to the Cerebral Blood Flow Alterations in Alzheimer's Dementia Continuum: An Original Study.Health science reports · 2025Article
- Epigallocatechin-3-Gallate Inhibits Oxidative Stress Through the Keap1/Nrf2 Signaling Pathway to Improve Alzheimer Disease.Molecular neurobiology · 2025Review
- Evaluation of machine learning models for the prediction of Alzheimer's: In search of the best performance.Brain, behavior, & immunity - health · 2025Article
- Exploring the global impact of obesity and diet on dementia burden: the role of national policies and sex differences.GeroScience · 2025Article
- Elevated gonadotropins and risk of dementia in Chinese adults aged over 80: a cross-sectional study.Frontiers in aging neuroscience · 2025Article
- Contribution of smoking to the global burden of bladder cancer from 1990 to 2021 and projections to 2046.Tobacco induced diseases · 2025Article
- A GBD 2021 study of Alzheimer's disease and other dementias attributable to metabolic risk factors and forecasts to 2045 in China.Frontiers in public health · 2025Article
- Rib and Sternum Fractures From Falls: Global Burden of Disease and Predictions.Biomedical engineering and computational biology · 2025Article
- Global Burden of Alzheimer's disease and other dementias in adults aged 65 years and older, 1991-2021: population-based study.Frontiers in public health · 2025Article
- Global, regional, and national burden of inflammatory bowel disease from 1990 to 2021: findings from the Global Burden of Disease 2021.Gastroenterology report · 2025Article
- From dementia prevention research to global FINGER-based multi-domain interventions and implementation strategies.Cerebral circulation - cognition and behavior · 2025Review
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Abstract
backgroundThe number of individuals with dementia is increasing, which negatively affects families, communities, and health care systems worldwide. The changes in the incidence of and mortality due to Alzheimer's disease and other forms of dementia at the national level in China have remained unknown over the past three decades.
methodsFollowing the general analytical strategy used in the Global Burden of Disease Study (GBD) 2019, the age- and sex-specific incidence and mortality rates for dementia in China were analyzed. Trends in the incidence of and mortality due to dementia from 1990 to 2019 were assessed by joinpoint regression analysis. The effects of age, period and cohort on the incidence of and mortality due to dementia were estimated by an age-period-cohort model.
resultsThe age-standardized incidence and mortality rates per 100,000 population were 103.83 (95% UI, 87.93-118.87) and 23.32 (95% UI, 5.66-61.31), respectively, for dementia in 2019. From 1990 to 2019, a significant average annual percentage change (AAPC) in the age-standardized incidence rate was observed in both males [0.49% (95% CI, 0.43-0.55%)] and females [0.31% (95% CI, 0.24-0.38%)], and the age-standardized mortality rate significantly increased in males [0.42% (95% CI, 0.31-0.53%)]. The population aged 55-59 years had the highest AAPC in the incidence of dementia [0.87% (95% CI, 0.81-0.93%)]. The age effect showed that the relative risks (RRs) of incident dementia and dementia-associated mortality increased with age among males and females, and individuals aged 60 years and older had significantly higher RRs. The RR of incident dementia increased with time, and the RR started to substantially increase in 2009. The cohort effect showed that the incidence decreased in successive birth cohorts.
conclusionAlzheimer's disease and other forms of dementia continue to become more common among males and females in China, and the associated mortality rate in males significantly increased from 1990 to 2019. Early interventions should be implemented to reduce the burden of dementia on individuals at high risk in China.
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