Evidence map›Paper›PMID 34539347›Full record

ArticleFrontiers in cellular neuroscience2021

Review and Hypothesis: A Potential Common Link Between Glial Cells, Calcium Changes, Modulation of Synaptic Transmission, Spreading Depression, Migraine, and Epilepsy-H

Robert Paul Malchow, Boriana K Tchernookova, Ji-In Vivien Choi, Peter J S Smith, Richard H Kramer, Matthew A Kreitzer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. ATP-mediated increase in HJournal of neurophysiology · 2024
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Robert Paul MalchowDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL, United States.
Boriana K TchernookovaDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL, United States.
Ji-In Vivien ChoiDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL, United States.
Peter J S SmithInstitute for Life Sciences, University of Southampton, Highfield Campus, Southampton, United Kingdom.
Richard H KramerDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Matthew A KreitzerDepartment of Biology, Indiana Wesleyan University, Marion, IN, United States.
University of Illinois Chicago · USIndiana Wesleyan University · USLoyola University Chicago · USMarine Biological Laboratory · USUniversity of California, Berkeley · US

Funding

UC Berkeley Vision Science COREP30EY003176 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RICHARD H KRAMER · 1985 to 2026
$16.4M
VOLTAMMETRIC DETECTION OF METAL IONSP41RR001395 · NCRR · MARINE BIOLOGICAL LABORATORY · PI SMITH, PETER JS · 1985 to 2010
$12.7M
NCRR NIH HHS P41 RR001395NEI NIH HHS P30 EY003176
6 · The paper itself

Abstract

There is significant evidence to support the notion that glial cells can modulate the strength of synaptic connections between nerve cells, and it has further been suggested that alterations in intracellular calcium are likely to play a key role in this process. However, the molecular mechanism(s) by which glial cells modulate neuronal signaling remains contentiously debated. Recent experiments have suggested that alterations in extracellular H

Indexed as

ATPepilepsygliaH+migraineMüller cellpHspreading depression

Identifiers

PMID34539347
PMCPMC8446203
OpenAlexW3196363896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.