Evidence map›Paper›PMID 34539168›Full record

ArticleJournal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems2021

Fabrication of a Multilayer Implantable Cortical Microelectrode Probe to Improve Recording Potential.

Xin Liu, Yelena Bibineyshvili, Denise A Robles, Andrew J Boreland, David J Margolis, David I Shreiber, Jeffrey D Zahn

Abstract read
In one paragraph

Article in Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Whole Cell Patch Clamp Electrophysiology in Human Neuronal Cells.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xin LiuDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854 USA.ORCID 0000-0002-7350-8281
Yelena BibineyshviliDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA.
Denise A RoblesDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854 USA.ORCID 0000-0002-6380-6605
Andrew J BorelandDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA.ORCID 0000-0002-1786-3473
David J MargolisDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA.ORCID 0000-0002-2678-4216
David I ShreiberDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854 USA.ORCID 0000-0001-8248-419X
Jeffrey D ZahnDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854 USA.ORCID 0000-0001-8712-752X

Funding

X-RAY STRUCTURE OF RIFM PROTEIN FROM THE BIOSYNTHESIS PATHWAY OF THE ANSAMYCIN AP41RR012408 · NCRR · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MARIUZZA, ROY A · 1998 to 2011
$32.2M
UMDNJ TRAINING GRANT IN BIOTECHNOLOGYT32GM008339 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI YARMUSH, MARTIN L · 1989 to 2019
$6.1M
Rutgers Biotechnology Training ProgramT32GM135141 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANN M. STOCK, Martin L Yarmush · 2020 to 2026
$3.5M
NRSA TrainingTL1TR003019 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI SCOTTO, KATHLEEN W. · 2019 to 2023
$1.9M
NCATS NIH HHS TL1 TR003019NCRR NIH HHS P41 RR012408NIGMS NIH HHS T32 GM008339NIGMS NIH HHS T32 GM135141
6 · The paper itself

Abstract

Intracortical neural probes are a key enabling technology for acquiring high fidelity neural signals within the cortex. They are viewed as a crucial component of brain-computer interfaces (BCIs) in order to record electrical activities from neurons within the brain. Smaller, more flexible, polymer-based probes have been investigated for their potential to limit the acute and chronic neural tissue response. Conventional methods of patterning electrodes and connecting traces on a single supporting layer can limit the number of recording sites which can be defined, particularly when designing narrower probes. We present a novel strategy of increasing the number of recording sites without proportionally increasing the size of the probe by using a multilayer fabrication process to vertically layer recording traces on multiple Parylene support layers, allowing more recording traces to be defined on a smaller probe width. Using this approach, we are able to define 16 electrodes on 4 supporting layers (4 electrodes per layer), each with a 30

Indexed as

Brain-computer interfacesflexible materialmulti-layer neural probeParylene C

Identifiers

PMID34539168
PMCPMC8445332

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.