Evidence map›Paper›PMID 34539144›Full record

ArticleWorld journal of gastroenterology2021

Intestinal ischemic manifestations of SARS-CoV-2: Results from the ABDOCOVID multicentre study.

Lorenzo Norsa, Pietro Andrea Bonaffini, Maja Caldato, Cristiana Bonifacio, Aurelio Sonzogni, Amedeo Indriolo, Clarissa Valle, Federica Furfaro, Alice Bonanomi, Paolo Niccolò Franco and 11 more

Open access · hybridAbstract readCase ReportsMulticenter Study
In one paragraph

Article in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Lorenzo NorsaDepartment of Pediatric Gastroenterology Hepatology and Transplantation, ASST Papa Giovanni XXIII, Bergamo 24127, Italy. lnorsa@asst-pg23.it.
Pietro Andrea BonaffiniDepartment of Radiology Papa Giovanni XXIII Bergamo, University of Milano-Bicocca, Milan 20126, Italy.
Maja CaldatoFondazione IRCCS Ca' Granda, Department of Emergency Medicine, Ospedale Maggiore Policlinico, Milano 20122, Italy.
Cristiana BonifacioDepartment of Radiology, Humanitas Clinical and Research Center, IRCCS, Rozzano 20089, Italy.
Aurelio SonzogniDepartment of Pathology, ASST Papa Giovanni XXIII, Bergamo 24127, Italy.
Amedeo IndrioloDepartment of Gastroenterology and Endoscopy, ASST Papa Giovanni XXIII, Bergamo 24127, Italy.
Clarissa ValleDepartment of Radiology Papa Giovanni XXIII Bergamo, University of Milano-Bicocca, Milan 20126, Italy.
Federica FurfaroIBD Center, Humanitas Clinical and Research Center IRCCS, Humanitas University, Rozzano 20089, Italy.
Alice BonanomiPost-Graduate School of Diagnostic Radiology, University of Milano-Bicocca, Milano 20126, Italy.
Paolo Niccolò FrancoPost-Graduate School of Diagnostic Radiology, University of Milano-Bicocca, Milano 20126, Italy.
Mauro GoriCardiovascular Department, ASST Papa Giovanni XXIII, Bergamo 24127, Italy.
Veronica SmaniaDepartment of Gastroenterology and Endoscopy, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.
Lucia ScaramellaDepartment of Gastroenterology and Endoscopy, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.
Laura ForzenigoDepartment of Radiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.
Maurizio VecchiDepartment of Gastroenterology and Endoscopy, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.
Monica SolbiatiFondazione IRCCS Ca' Granda, Department of Emergency Medicine, Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milano 20122, Italy.
Giorgio CostantinoFondazione IRCCS Ca' Granda, Department of Emergency Medicine, Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milano 20122, Italy.
Silvio DaneseIBD Center, Humanitas Clinical and Research Center IRCCS, Humanitas University, Rozzano 20089, Italy.
Lorenzo D'AntigaDepartment of Pediatric Gastroenterology Hepatology and Transplantation, ASST Papa Giovanni XXIII, Bergamo 24127, Italy.
Sandro SironiDepartment of Radiology Papa Giovanni XXIII Bergamo, University of Milano-Bicocca, Milan 20126, Italy.
Luca ElliDepartment of Gastroenterology and Endoscopy, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITOspedale Papa Giovanni XXIII · ITUniversity of Milano-Bicocca · ITHumanitas University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntestinal ischemia has been described in case reports of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (coronavirus disease 19, COVID-19).

aimTo define the clinical and histological, characteristics, as well as the outcome of ischemic gastrointestinal manifestations of SARS-CoV-2 infection.

methodsA structured retrospective collection was promoted among three tertiary referral centres during the first wave of the pandemic in northern Italy. Clinical, radiological, endoscopic and histological data of patients hospitalized for COVID-19 between March 1

resultsAmong 2929 patients, 21 (0.7%) showed gastrointestinal ischemic manifestations either as presenting symptom or during hospitalization. Abdominal CT showed bowel distention in 6 patients while signs of colitis/enteritis in 12. Three patients presented thrombosis of main abdominal veins. Endoscopy, when feasible, confirmed the diagnosis (6 patients). Surgical resection was necessary in 4/21 patients. Histological tissue examination showed distinctive features of endothelial inflammation in the small bowel and colon. Median hospital stay was 9 d with a mortality rate of 39%.

conclusionGastrointestinal ischemia represents a rare manifestation of COVID-19. A high index of suspicion should lead to investigate this complication by CT scan, in the attempt to reduce its high mortality rate. Histology shows atypical feature of ischemia with important endotheliitis, probably linked to thrombotic microangiopathies.

Indexed as

COVID-19Gastrointestinal DiseasesHumansPandemicsRetrospective StudiesSARS-CoV-2CoronavirusCOVID-19Endothelial inflammationIschemic colitisSmall bowel ischemia

Identifiers

PMID34539144
PMCPMC8409161
OpenAlexW3193527397

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.