Evidence map›Paper›PMID 34538875›Full record

ArticleThe British journal of psychiatry : the journal of mental science2021

Unravelling the contribution of complex trauma to psychopathology and cognitive deficits: a cohort study.

Stephanie J Lewis, Karestan C Koenen, Antony Ambler, Louise Arseneault, Avshalom Caspi, Helen L Fisher, Terrie E Moffitt, Andrea Danese

Open access · hybridAbstract readTwin Study
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Growing Up with Parental Mental Illness and Post-Traumatic Growth.Journal of child & adolescent trauma · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Autistic traits in childhood and post-traumatic stress disorder as young adults: a cohort study.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Article
  8. Article
  9. Article
  10. Psychopathological symptoms in school-aged children after a traumatic event.Child and adolescent psychiatry and mental health · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Complex Racial Trauma: Evidence, Theory, Assessment, and Treatment.Perspectives on psychological science : a journal of the Association for Psychological Science · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Stephanie J LewisKing's College London, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, UK.
Karestan C KoenenHarvard T.H. Chan School of Public Health, Department of Epidemiology, USA.
Antony AmblerKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, UK.
Louise ArseneaultKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, UK.
Avshalom CaspiKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, UK; Duke University, Department of Psychology and Neuroscience, USA; Duke University, Department of Psychiatry and Behavioral Sciences, USA; Duke University, Center for Genomic and Computational Biology, USA.
Helen L FisherKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, UK; King's College London, ESRC Centre for Society & Mental Health, UK.
Terrie E MoffittKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, UK; Duke University, Department of Psychology and Neuroscience, USA; Duke University, Department of Psychiatry and Behavioral Sciences, USA; Duke University, Center for Genomic and Computational Biology, USA.
Andrea DaneseKing's College London, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, UK; King's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, UK; South London and Maudsley NHS Foundation Trust, National and Specialist CAMHS Clinic for Trauma, Anxiety, and Depression, UK.
King's College London · GBDuke University · USHarvard University · US

Funding

Neuropsychological and genomic signatures of violence exposure in childhoodR01HD077482 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2013 to 2018
$2.8M
Medical Research Council G1002190Medical Research Council MR/S001492/1NICHD NIH HHS R01 HD077482
6 · The paper itself

Abstract

Background: Complex traumas are traumatic experiences that involve multiple interpersonal threats during childhood or adolescence, such as repeated abuse. Complex traumas are hypothesized to lead to more severe psychopathology and poorer cognitive function than other non-complex traumas. However, empirical testing of this hypothesis has been limited to clinical/convenience samples and cross-sectional designs. Aims: To investigate psychopathology and cognitive function in young people exposed to complex, non-complex, or no trauma from a population-representative longitudinal cohort, and to consider the role of pre-existing vulnerabilities. Method: Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a population-representative birth-cohort of 2,232 British children. At age 18 years (93% participation), we assessed lifetime exposure to complex and non-complex trauma, past-year psychopathology, and current cognitive function. We also prospectively assessed early childhood vulnerabilities: internalizing and externalizing symptoms at age 5, IQ at age 5, family history of mental illness, family socioeconomic status, and sex. Results: Participants exposed to complex trauma had more severe psychopathology and poorer cognitive function at age 18 compared to both trauma-unexposed participants and those exposed to non-complex trauma. Early childhood vulnerabilities predicted risk of later complex trauma exposure, and largely explained associations of complex trauma with cognitive deficits, but not with psychopathology. Conclusions: By conflating complex and non-complex traumas, current research and clinical practice under-estimate the severity of psychopathology, cognitive deficits, and pre-existing vulnerabilities linked with complex trauma. A better understanding of the mental health needs of people exposed to complex trauma could inform the development of new effective interventions.

Indexed as

Mental DisordersPsychopathologyAdolescentChildChild, PreschoolCognitionCohort StudiesCross-Sectional StudiesHumansLongitudinal Studies

Identifiers

PMID34538875
PMCPMC7611677
OpenAlexW3159639034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.