ArticleJACC. Cardiovascular imaging2022
Dynamic Myocardial Perfusion CT for the Detection of Hemodynamically Significant Coronary Artery Disease.
Article in JACC. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02810795 (Dynamic Stress Perfusion ct for Detection of Inducible Myocardial Ischemia), which is not on this map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dynamic Stress Perfusion ct for Detection of Inducible Myocardial Ischemia
Who cites it
57 citing papers in PubMed.
- Coronary artery imaging in Kawasaki disease: recent updates in imaging techniques and clinical indications.The international journal of cardiovascular imaging · 2026Review
- Stress CT myocardial perfusion imaging after arterial switch operation for transposition of the great arteries.European heart journal. Imaging methods and practice · 2026Article
- CAD-RADS: A Standardized Reporting System for Coronary CT Angiography.Journal of the Korean Society of Radiology · 2026Review
- Fractal analysis of dynamic stress myocardial CT perfusion decouples diagnostic accuracy for obstructive coronary artery disease from remote flow.Japanese journal of radiology · 2026Article
- Application of low-dose "one-stop" myocardial computed tomography perfusion imaging in coronary artery disease.Quantitative imaging in medicine and surgery · 2026Article
- Unmasking 5-fluorouracil cardiotoxicity: The clinical utility of dynamic myocardial CT perfusion: A case report.Radiology case reports · 2026Article
- Cost-effective integration of dynamic myocardial CT perfusion in the assessment of symptomatic coronary artery disease.European radiology · 2026Article
- Quantitative myocardial perfusion imaging across PET, SPECT, CMR, and CT.Frontiers in radiology · 2026Review
- Multimodality Cardiovascular Imaging in Patients After Coronary Artery Bypass Grafting: Diagnosis and Risk Stratification.Diagnostics (Basel, Switzerland) · 2025Review
- Personalized and uncertainty-aware coronary hemodynamics simulations: From Bayesian estimation to improved multi-fidelity uncertainty quantification.Computer methods and programs in biomedicine · 2025Article
- Radiomic phenotype of epicardial adipose tissue derived from coronary artery calcium score predicts myocardial ischemia.La Radiologia medica · 2025Article
- Fractional flow reserve calculation optimized by myocardial computed tomography perfusion information.Quantitative imaging in medicine and surgery · 2025Article
- Protocol optimization and myocardial blood flow quantification in dynamic myocardial perfusion CT-where do we stand?European radiology · 2025Article
- Diagnostic Performance of Dynamic Myocardial Perfusion Imaging Using Third-Generation Dual-Source Computed Tomography in Patients with Intermediate Pretest Probability of Coronary Artery Disease.Journal of cardiovascular development and disease · 2025Article
- Feasibility, Added Value, and Radiation Dose of Combined Coronary CT Angiography and Stress Dynamic CT Myocardial Perfusion Imaging in Moderate Coronary Artery Disease: A Real-World Study.Journal of cardiovascular development and disease · 2025Article
- Relationship between microvascular status and diagnostic performance of stress dynamic CT perfusion imaging.European radiology · 2025Article
- State of the art of CT myocardial perfusion.La Radiologia medica · 2025Review
- Impact of physiological and coronary artery disease risk factors on myocardial perfusion in stress computed tomography myocardial perfusion imaging.Scientific reports · 2025Article
- Ischemia and Anatomy in the New 2024 European Guidelines for Chronic Coronary Syndromes: Update and Comparison of Recommendations.Journal of the Saudi Heart Association · 2025Review
- How to perform and evaluate a myocardial perfusion imaging by computed tomography.European heart journal. Imaging methods and practice · 2025Review
Corrections and comments
- Commented on by
Authors and funding
24 authors.
Funding
Abstract
objectivesIn this international, multicenter study, using third-generation dual-source computed tomography (CT), we investigated the diagnostic performance of dynamic stress CT myocardial perfusion imaging (CT-MPI) in addition to coronary CT angiography (CTA) compared to invasive coronary angiography (ICA) and invasive fractional flow reserve (FFR).
backgroundCT-MPI combined with coronary CTA integrates coronary artery anatomy with inducible myocardial ischemia, showing promising results for the diagnosis of hemodynamically significant coronary artery disease in single-center studies.
methodsAt 9 centers in Europe, Japan, and the United States, 132 patients scheduled for ICA were enrolled; 114 patients successfully completed coronary CTA, adenosine-stress dynamic CT-MPI, and ICA. Invasive FFR was performed in vessels with 25% to 90% stenosis. Data were analyzed by independent core laboratories. For the primary analysis, for each coronary artery the presence of hemodynamically significant obstruction was interpreted by coronary CTA with CT-MPI compared to coronary CTA alone, using an FFR of ≤0.80 and angiographic severity as reference. Territorial absolute myocardial blood flow (MBF) and relative MBF were compared using C-statistics.
resultsICA and FFR identified hemodynamically significant stenoses in 74 of 289 coronary vessels (26%). Coronary CTA with ≥50% stenosis demonstrated a per-vessel sensitivity, specificity, and accuracy for the detection of hemodynamically significant stenosis of 96% (95% CI: 91%-100%), 72% (95% CI: 66%-78%), and 78% (95% CI: 73%-83%), respectively. Coronary CTA with CT-MPI showed a lower sensitivity (84%; 95% CI: 75%-92%) but higher specificity (89%; 95% CI: 85%-93%) and accuracy (88%; 95% CI: 84%-92%). The areas under the receiver-operating characteristic curve of absolute MBF and relative MBF were 0.79 (95% CI: 0.71-0.86) and 0.82 (95% CI: 0.74-0.88), respectively. The median dose-length product of CT-MPI and coronary CTA were 313 mGy·cm and 138 mGy·cm, respectively.
conclusionsDynamic CT-MPI offers incremental diagnostic value over coronary CTA alone for the identification of hemodynamically significant coronary artery disease. Generalized results from this multicenter study encourage broader consideration of dynamic CT-MPI in clinical practice. (Dynamic Stress Perfusion CT for Detection of Inducible Myocardial Ischemia [SPECIFIC]; NCT02810795).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.