Evidence map›Paper›PMID 34538574›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2021

Individual localization value of resting-state fMRI in epilepsy presurgical evaluation: A combined study with stereo-EEG.

Yingying Tang, Joon Yul Choi, Andreas Alexopoulos, Hiroatsu Murakami, Masako Daifu-Kobayashi, Qin Zhou, Imad Najm, Stephen E Jones, Zhong Irene Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yingying TangDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA.
Joon Yul ChoiEpilepsy Center, Cleveland Clinic, Cleveland, OH, USA.
Andreas AlexopoulosEpilepsy Center, Cleveland Clinic, Cleveland, OH, USA.
Hiroatsu MurakamiEpilepsy Center, Cleveland Clinic, Cleveland, OH, USA.
Masako Daifu-KobayashiEpilepsy Center, Cleveland Clinic, Cleveland, OH, USA.
Qin ZhouEpilepsy Center, Cleveland Clinic, Cleveland, OH, USA.
Imad NajmEpilepsy Center, Cleveland Clinic, Cleveland, OH, USA.
Stephen E JonesImaging Institute, Cleveland Clinic, Cleveland, OH, USA.
Zhong Irene WangEpilepsy Center, Cleveland Clinic, Cleveland, OH, USA. Electronic address: wangi2@ccf.org.
Cleveland Clinic · USSichuan University · CN

Funding

MR Fingerprinting for EpilepsyR01NS109439 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI Dan Ma, Zhong Irene Wang · 2019 to 2026
$4.2M
NINDS NIH HHS R01 NS109439
6 · The paper itself

Abstract

objectiveTo examine the individual-patient-level localization value of resting-state functional MRI (rsfMRI) metrics for the seizure onset zone (SOZ) defined by stereo-electroencephalography (SEEG) in patients with medically intractable focal epilepsies.

methodsWe retrospectively included 19 patients who underwent SEEG implantation for epilepsy presurgical evaluation. Voxel-wise whole-brain analysis was performed on 3.0 T rsfMRI to generate clusters for amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo) and degree centrality (DC), which were co-registered with the SEEG-defined SOZ to evaluate their spatial overlap. Subgroup and correlation analyses were conducted for various clinical characteristics.

resultsALFF demonstrated concordant clusters with SEEG-defined SOZ in 73.7% of patients, with 93.3% sensitivity and 77.8% PPV. The concordance rate showed no significant difference when subgrouped by lesional/non-lesional MRI, SOZ location, interictal epileptiform discharges on scalp EEG, pathology or seizure outcomes. No significant correlation was seen between ALFF concordance rate and epilepsy duration, seizure-onset age, seizure frequency or number of antiseizure medications. ReHo and DC did not achieve favorable concordance results (10.5% and 15.8%, respectively). All concordant clusters showed regional activation, representing increased neural activities.

conclusionALFF had high concordance rate with SEEG-defined SOZ at individual-patient level. SIGNIFICANCE: ALFF activation on rsfMRI can add localizing information for the noninvasive presurgical workup of intractable focal epilepsies.

Indexed as

AdolescentAdultAnterior Temporal LobectomyElectroencephalographyEpilepsyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPostoperative ComplicationsPreoperative PeriodAmplitude of low-frequency fluctuations (ALFF)EpilepsyPresurgical evaluationresting-state functional magnetic resonance imaging (rsfMRI)Stereo-electroencephalography (SEEG)

Identifiers

PMID34538574
PMCPMC8629929
OpenAlexW3198673478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.