SynthesisHypertension (Dallas, Tex. : 1979)2021
Association Between Blood Pressure Variability With Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis.
Abstract readMeta-AnalysisSystematic Review
In one paragraph
Synthesis in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations of Blood Pressure Parameters with Cognitive Decline and Dementia: A Systematic Review of Reviews.American journal of hypertension · 2026Pooled it
- Association between Blood Pressure and Post-Stroke Cognitive Impairment: A Meta-Analysis.Reviews in cardiovascular medicine · 2024Pooled it
- Effect of Remimazolam and Propofol on Intraoperative Blood Pressure Variability in Patients Undergoing Endovascular Embolization of Intracranial Aneurysms.Drug design, development and therapy · 2026Trial
- Association Between Visit-to-Visit Blood Pressure Variability and Incidence of Atrial Fibrillation in Hypertensive Patients: A Post-Hoc Analysis of the SPRINT Trial.Journal of clinical hypertension (Greenwich, Conn.) · 2025Trial
- Comparison of visit-to-visit blood pressure variability and time in target range in predicting risk for cognitive outcomes in the SPRINT trial.Journal of Alzheimer's disease : JAD · 2025Trial
- 24-Hour Blood Pressure Variability Via Ambulatory Monitoring and Risk for Probable Dementia in the SPRINT Trial.The journal of prevention of Alzheimer's disease · 2024Trial
- Blood Pressure Variability and Cerebral Perfusion Decline: A Post Hoc Analysis of the SPRINT MIND Trial.Journal of the American Heart Association · 2023Trial
- Blood Pressure Variability and Cognitive Decline: A Post Hoc Analysis of the SPRINT MIND Trial.American journal of hypertension · 2023Trial
- Insulin resistance is potentially associated with 24-h blood pressure variability related to blunted sympathetic reactivity in older adults with hypertension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Blood pressure variability and frailty: mechanisms, evidence, and clinical implications.International urology and nephrology · 2026Review
- Association of Alzheimer's disease blood-based biomarkers and visit-to-visit blood pressure variability: The HABS-HD study.Journal of Alzheimer's disease : JAD · 2026Article
- Visit-to-visit systolic blood pressure variability, blood pressure treatment intensity, and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Long-Term Blood Pressure Variability in Cerebral Amyloid Angiopathy is Associated with Ischemic Brain Injury and Cognitive Decline.Journal of the American Heart Association · 2026Observational
- Epidemiological and clinical evidence on blood pressure management for the prevention of dementia: striving for a healthy 100-year life.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Article
- Cumulative Blood Pressure as a Marker of Early Cognitive Decline.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Visit-to-visit blood pressure variability, brain MRI measures, and cognition in non-demented older adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Medication Adherence, Blood Pressure Variability, and Mild Cognitive Impairment.Journal of the American Heart Association · 2026Article
- Visit-to-visit blood pressure variability and dementia risk after considering antihypertensive treatment: real-world data from the Japanese National Health Insurance.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Impact of long-term systolic blood pressure on cognitive disorder risk: Across different age groups and antihypertensive medication timing.Journal of Alzheimer's disease : JAD · 2026Observational
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Rianne A A de HeusRadboud University Medical Center, Department of Geriatric Medicine, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., J.A.H.R.C.).
Christophe TzourioBordeaux Population Health, Univeristy of Bordeaux, Inserm, Team Healthy, UMR 1219, CHU Bordeaux, France (C.T.).ORCID 0000-0002-6517-2984
Emily Jo Lynn LeeAdelaide Medical School (E.J.L.L., M.O., A.D.V., P.J.T.), Freemasons Centre for Male Health and Wellbeing, The University of Adelaide, Australia.ORCID 0000-0003-1097-1567
Melissa OpozdaAdelaide Medical School (E.J.L.L., M.O., A.D.V., P.J.T.), Freemasons Centre for Male Health and Wellbeing, The University of Adelaide, Australia.
Andrew D VincentAdelaide Medical School (E.J.L.L., M.O., A.D.V., P.J.T.), Freemasons Centre for Male Health and Wellbeing, The University of Adelaide, Australia.
Kaarin J AnsteySchool of Psychology (K.J.A.), University of New South Wales, Sydney, Australia.
Albert HofmanDepartment of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA (A.H., Y.M.).
Kazuomi KarioDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan (K.K.).ORCID 0000-0002-8251-4480
Simona LattanziNeurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy (S.L.).ORCID 0000-0001-8748-0083
Lenore J LaunerIntramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L.).ORCID 0000-0002-3238-7612
Yuan MaDepartment of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA (A.H., Y.M.).ORCID 0000-0002-0207-3620
Rajiv MahajanORCID 0000-0003-3375-5568
Simon P MooijaartUniversity of Adelaide, Lyell McEwin Hospital (R.M.), South Australian Health and Medical Research Institute, Australia.ORCID 0000-0003-3106-3568
Michiaki NagaiDepartment of Cardiology, Hiroshima City Asa Hospital, Japan (M.N.).
Ruth PetersNeuroscience Research Australia (R.P.), University of New South Wales, Sydney, Australia.ORCID 0000-0003-0148-3617
Deborah TurnbullSchool of Psychology (D.T.), Freemasons Centre for Male Health and Wellbeing, The University of Adelaide, Australia.
Yuichiro YanoYokohama City University Center for Novel and Exploratory Clinical Trials, Yokohama City University Hospital, Japan (Y.Y.).ORCID 0000-0002-2565-7290
VARIABLE BRAIN Consortium
Jurgen A H R ClaassenRadboud University Medical Center, Department of Geriatric Medicine, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., J.A.H.R.C.).
Phillip J TullyAdelaide Medical School (E.J.L.L., M.O., A.D.V., P.J.T.), Freemasons Centre for Male Health and Wellbeing, The University of Adelaide, Australia.ORCID 0000-0003-2807-1313
Funding
No grant is acknowledged in the PubMed record.
Abstract
[Figure: see text].
Indexed as
Blood PressureCognitive DysfunctionDementiaHumansHypertensionRiskAlzheimer diseaseblood pressurecerebrovascular disordersdementiahemodynamicsmeta-analysisstroke
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.