Evidence map›Paper›PMID 34538100›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure.

Madeleine R Paterson, Kristy L Jackson, Malathi S I Dona, Gabriella E Farrugia, Bruna Visniauskas, Anna M D Watson, Chad Johnson, Minolfa C Prieto, Roger G Evans, Fadi J Charchar and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. microRNA and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2025
    Review
  4. Expert opinion on therapeutic targets · 2024
    Review
  5. Article
  6. MicroRNA-181 in cardiovascular disease: Emerging biomarkers and therapeutic targets.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Madeleine R PatersonHypertension Research Laboratory, School of Biological Sciences, Faculty of Science (M.R.P., F.Z.M.), Monash University, Melbourne, Australia.
Kristy L JacksonNeuropharmacology Laboratory (M.R.P., K.L.J., A.M.D.W., G.A.H.), Baker Heart and Diabetes Institute, Melbourne, Australia.
Malathi S I DonaCardiac Cellular Systems Laboratory (M.S.I.D., G.E.F.), Baker Heart and Diabetes Institute, Melbourne, Australia.ORCID 0000-0002-0337-4417
Gabriella E FarrugiaCardiac Cellular Systems Laboratory (M.S.I.D., G.E.F.), Baker Heart and Diabetes Institute, Melbourne, Australia.
Bruna VisniauskasDepartment of Physiology, School of Medicine, Tulane University, New Orleans, LA (B.V., M.C.P.).
Anna M D WatsonDepartment of Diabetes, Central Clinical School (A.M.D.W.), Monash University, Melbourne, Australia.
Chad JohnsonMonash Micro Imaging (C.J.), Monash University, Melbourne, Australia.
Minolfa C PrietoDepartment of Physiology, School of Medicine, Tulane University, New Orleans, LA (B.V., M.C.P.).ORCID 0000-0002-0199-3193
Roger G EvansCardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology (R.G.E.), Monash University, Melbourne, Australia.ORCID 0000-0002-9241-0757
Fadi J CharcharHealth Innovation and Transformation Centre, Federation University, Ballarat, Australia (F.J.C.).
Alexander R PintoDrug Discovery Biology, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University Parkville, Australia (K.L.J., A.R.P.).ORCID 0000-0001-6421-4970
Francine Z Marques *Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science (M.R.P., F.Z.M.), Monash University, Melbourne, Australia.ORCID 0000-0003-4920-9991
Geoffrey A Head *Department of Pharmacology (G.A.H.), Monash University, Melbourne, Australia.ORCID 0000-0002-7623-137X
Baker Heart and Diabetes Institute · AUTulane University · USDiscovery Institute · USFederation University · AULa Trobe University · AUMonash Health · AU

Funding

PLEIOTROPIC EFFECTS OF PRORENIN RECEPOR IN COLLECTING DUCT AND INTRARENAL RAS ACTIVATIONR01DK104375 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI PRIETO, MINOLFA C · 2014 to 2018
$1.7M
NIDDK NIH HHS R01 DK104375
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

TranscriptomeAnimalsBlood PressureFibrosisGene Expression ProfilingGene Expression RegulationGene OntologyHumansHypertensionInflammationKidneyMiceMice, Inbred C57BLMice, KnockoutMicroRNAsReninMicroRNAsmirn181 microRNA, mouseReninblood pressuremicroRNAsreninsaltssodium

Identifiers

PMID34538100
PMCPMC8573069
OpenAlexW3200053866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.