ReviewArchives of pharmacal research2021
Understanding of sarcopenia: from definition to therapeutic strategies.
Review in Archives of pharmacal research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Network meta-analysis of the intervention effects of different exercise measures on Sarcopenia in cancer patients.BMC public health · 2024Pooled it
- Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Quantifying the Enhancement of Sarcopenic Skeletal Muscle Preservation Through a Hybrid Exercise Program: Randomized Controlled Trial.JMIR aging · 2024Trial
- Association Between Non-traditional Lipid Indices and Sarcopenia: Evidence from a Prospective Chinese Cohort Study.Current medical science · 2026Article
- Advances in electrical stimulation-based therapeutic technologies for sarcopenia prevention and treatment.Bioactive materials · 2026Review
- Novel biomarkers for sarcopenia: a narrative review.Journal of orthopaedic surgery and research · 2026Review
- Review
- European Working Group on Sarcopenia in Older People Algorithm: Step-by-Step Relation With Length of Hospitalization.Journal of the American Geriatrics Society · 2026Article
- Multimodal Therapeutic Strategies for the Management of Sarcopenia and Frailty in Chronic Obstructive Pulmonary Disease: A Narrative Review.Nutrients · 2026Review
- Sarcopenia, Obesity, and Sarcopenic Obesity in Relation to Functional Limitations in Older Adults.Journal of clinical medicine · 2026Article
- Correlation between ZJU index and sarcopenia in elderly inpatients and its predictive value.Frontiers in medicine · 2026Article
- Risk prediction of sarcopenia in a large health checkup population: development and validation of a dynamic online nomogram.Frontiers in public health · 2026Article
- Article
- Exercise-Induced Biomarker Modulation in Sarcopenia: From Inflamm-Aging to Muscle Regeneration.Sports (Basel, Switzerland) · 2025Review
- Associations between physical activity, socioeconomic and sociodemographic factors, and risk of sarcopenia in older adults in Northeast Brazil.BMC public health · 2025Article
- Review
- Energy metabolism in different skeletal muscles and muscle fibers: implications for injury and dietary supplementation.Pflugers Archiv : European journal of physiology · 2025Review
- Nrf2 pathway potentially confers protection against cigarette smoke-induced sarcopenia in a mouse model.European journal of medical research · 2025Article
- The impact of sarcopenia on the efficacy of posterior surgical treatment for degenerative lumbar scoliosis.BMC surgery · 2025Article
- Diagnostic Value of Point-of-Care Ultrasound for Sarcopenia in Geriatric Patients Hospitalized for Hip Fracture.Journal of clinical medicine · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia refers to the gradual loss of skeletal muscle mass and function along with aging and is a social burden due to growing healthcare cost associated with a super-aging society. Therefore, researchers have established guidelines and tests to diagnose sarcopenia. Several studies have been conducted actively to reveal the cause of sarcopenia and find an economic therapy to improve the quality of life in elderly individuals. Sarcopenia is caused by multiple factors such as reduced regenerative capacity, imbalance in protein turnover, alteration of fat and fibrotic composition in muscle, increased reactive oxygen species, dysfunction of mitochondria and increased inflammation. Based on these mechanisms, nonpharmacological and pharmacological strategies have been developed to prevent and treat sarcopenia. Although several studies are currently in progress, no treatment is available yet. This review presents the definition of sarcopenia and summarizes recent understanding on the detailed mechanisms, diagnostic criteria, and strategies for prevention and treatment.
Indexed as
Identifiers
34537916What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.