ArticleThe Journal of clinical endocrinology and metabolism2022
Associations of Age at Menopause With Postmenopausal Bone Mineral Density and Fracture Risk in Women.
Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- The effect of different traditional Chinese exercises on bone mineral density in menopausal women: a systematic review and network meta-analysis.Frontiers in public health · 2024Pooled it
- The effect and safety of Tai Chi on bone health in postmenopausal women: A meta-analysis and trial sequential analysis.Frontiers in aging neuroscience · 2022Pooled it
- Ovarian function recovery in breast cancer patients receiving adjuvant anastrozole treatment: updated results from the phase 3 DATA trial.Breast cancer research and treatment · 2024Trial
- Sex- and age-specific patterns in bone, muscle, and fat across adulthood and their relation to osteosarcopenic adiposity phenotype: a cross-sectional study.GeroScience · 2026Article
- Multimodal profiling establishes ovarian fibrosis as a measurable and targetable hallmark of human reproductive aging.Research square · 2026Article
- Effects of Mind-Body Exercise on Bone Health in Perimenopausal Women: A Systematic Review and Three-Level Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Effects of weighted vest on bone health and body fat in middle-aged and older adults: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Later menopause confers no additional protection against osteoporosis in older women.Endocrine connections · 2026Article
- Generalizable framework for multi-site bone density prediction using non-dominant wrist optical biomarkers.Biomedical optics express · 2026Article
- Risk Factors for Osteoporotic Vertebral Fractures in Postmenopausal Women: A Cross-Sectional Study.Journal of orthopaedic case reports · 2026Article
- Acute anomalous high-temperature exposure impacts on mouse ovaries.Journal of assisted reproduction and genetics · 2026Article
- What is the burden of fractures for a nation? An analysis of statutory health insurance cases in Germany.BMJ public health · 2026Article
- Interplay of menopause, coronary artery calcium score and cardiovascular disease risk.World journal of cardiology · 2025Article
- Unveiling risk factors and predicting osteoporosis through bone density based aging model: a community-based cohort in Guangdong, China.BMC musculoskeletal disorders · 2025Article
- Tai Chi Exercise and Bone Health in Women at Perimenopausal and Postmenopausal Stages: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Genome-wide insights of shared genetic architecture between menstrual traits and bone mineral density.Endocrine connections · 2025Article
- Association between preoperative persistent hyperglycemia and postoperative length of hospital in geriatric hip fracture patients.BMC geriatrics · 2025Article
- Association of reproductive characteristics with osteoporosis and FRAX scores in Chinese postmenopausal women: a QCT-based cross-sectional study.Scientific reports · 2025Article
- Patterns of Bone Mineral Density Loss at Multiple Skeletal Sites Following Recent Menopause in Users and Non-Users of Menopausal Hormone Therapy.Calcified tissue international · 2025Article
- The U-curve associations of birth interval with prevalence of osteoarthritis in postmenopausal women.Aging clinical and experimental research · 2025Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
contextMenopause before age 45 is a risk factor for fractures, but menopause occurs at age ≥45 in ~90% of women.
objectiveTo determine, in women with menopause at age ≥45, whether (1) years since the final menstrual period (FMP) is more strongly associated with postmenopausal bone mineral density (BMD) than chronological age and (2) lower age at FMP is related to more fractures. DESIGN AND
settingThe Study of Women's Health Across the Nation, a longitudinal cohort study of the menopause transition (MT).
participantsA diverse cohort of ambulatory women (pre- or early perimenopausal at baseline, with 15 near-annual follow-up assessments).
main outcome measuresPostmenopausal lumbar spine (LS) or femoral neck (FN) BMD (n = 1038) and time to fracture (n = 1554).
resultsAdjusted for age, body mass index (BMI), cigarette use, alcohol intake, baseline LS or FN BMD, baseline MT stage, and study site using multivariable linear regression, each additional year after the FMP was associated with 0.006 g/cm2 (P < 0.0001) and 0.004 g/cm2 (P < 0.0001) lower postmenopausal LS and FN BMD, respectively. Age was not related to FN BMD independent of years since FMP. In Cox proportional hazards regression, accounting for race/ethnicity, BMI, cigarette use, alcohol intake, prior fracture, diabetes status, exposure to bone-modifying medications/supplements, and study site, the hazard for incident fracture was 5% greater for each 1-year decrement in age at FMP (P = 0.02).
conclusionsYears since the FMP is more strongly associated with postmenopausal BMD than chronological age, and earlier menopause is associated with more fractures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.