SynthesisThe Journal of clinical endocrinology and metabolism2022
Clinical Utility of Anti-Mullerian Hormone in Pediatrics.
Synthesis in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- The feasibility of ovarian tissue cryopreservation in selected females after hematopoietic stem cell transplantation.Bone marrow transplantation · 2026Article
- Relative Sertoli-cell FSH hyporesponsiveness as a potential contributor to sperm DNA fragmentation: a hypothesis-driven narrative review and proposal of the FERTILE framework.Frontiers in urology · 2026Article
- Article
- Effects of Endometriosis on Anti-Müllerian Hormone.Journal of clinical medicine · 2025Article
- Ovarian function in adolescents and young adults undergoing cancer treatment: biochemical and ultrasound marker analysis.Endocrine connections · 2025Article
- Clinical utility of anti-Müllerian hormone in female children and adolescents.Hormones (Athens, Greece) · 2025Review
- Assessment of anti-Müllerian hormone levels as a reproductive indicator in Japanese Black cattle.The Journal of reproduction and development · 2024Article
- Persistent Müllerian Duct Syndrome with Supernumerary Testicles Due to a Novel Homozygous Variant in theDiagnostics (Basel, Switzerland) · 2024Article
- Anti-Müllerian hormone, testicular descent and cryptorchidism.Frontiers in endocrinology · 2024Review
- Gonadal Function in Female Adolescent and Young Adult Survivors of Childhood Cancer.Cancer research and treatment · 2023Article
- The Stability of the Anti-Müllerian Hormone in Serum and Plasma Samples under Various Preanalytical Conditions.Diagnostics (Basel, Switzerland) · 2023Article
- Anti-Müllerian hormone beyond an ovarian reserve marker: the relationship with the physiology and pathology in the life-long follicle development.Frontiers in endocrinology · 2023Review
- Paediatric Wolfram syndrome Type 1: should gonadal dysfunction be part of the diagnostic criteria?Frontiers in endocrinology · 2023Article
- Reference intervals of anti-Müllerian hormone in Korean women.Journal of clinical laboratory analysis · 2022Article
- Categorization of differences of sex development among Egyptian children and the role of antimullerian hormone and inhibin B.Frontiers in endocrinology · 2022Article
- AMH Regulation by Steroids in the Mammalian Testis: Underlying Mechanisms and Clinical Implications.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
contextAnti-Mullerian hormone (AMH) was originally described in the context of sexual differentiation in the male fetus but has gained prominence now as a marker of ovarian reserve and fertility in females. In this mini-review, we offer an updated synopsis on AMH and its clinical utility in pediatric patients. DESIGN AND
resultsA systematic search was undertaken for studies related to the physiology of AMH, normative data, and clinical role in pediatrics. In males, AMH, secreted by Sertoli cells, is found at high levels prenatally and throughout childhood and declines with progression through puberty to overlap with levels in females. Thus, serum AMH has clinical utility as a marker of testicular tissue in males with differences in sexual development and cryptorchidism and in the evaluation of persistent Mullerian duct syndrome. In females, serum AMH has been used as a predictive marker of ovarian reserve and fertility, but prepubertal and adolescent AMH assessments need to be interpreted cautiously. AMH is also a marker of tumor burden, progression, and recurrence in germ cell tumors of the ovary.
conclusionsAMH has widespread clinical diagnostic utility in pediatrics but interpretation is often challenging and should be undertaken in the context of not only age and sex but also developmental and pubertal stage of the child. Nonstandardized assays necessitate the need for assay-specific normative data. The recognition of the role of AMH beyond gonadal development and maturation may usher in novel diagnostic and therapeutic applications that would further expand its utility in pediatric care.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.