Evidence map›Paper›PMID 34537827›Full record

Trial reportAmerican journal of hypertension2022

Effects of Vitamin D Supplementation on Orthostatic Hypotension: Results From the STURDY Trial.

Stephen P Juraschek, Edgar R Miller, Amal A Wanigatunga, Jennifer A Schrack, Erin D Michos, Christine M Mitchell, Rita R Kalyani, Lawrence J Appel

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled TrialAdaptive Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02166333 (Vitamin D Supplements to Prevent Falls in Older Adults), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02166333 naterminatednot on this map

Vitamin D Supplements to Prevent Falls in Older Adults: A Dose-Response Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2015 to 2019Enrolled688ConditionsVitamin D Deficiency, FallsArms200 IU/d cholecalciferol, 1000 IU/d cholecalciferol, 2000 IU/d cholecalciferol, 4000 IU/d cholecalciferol
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Associations of Hypertension and Orthostatic Hypotension With Subclinical Cardiovascular Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Trial
  2. Trial
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Stephen P JuraschekDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-4168-2696
Edgar R MillerDepartment of Medicine, The Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Amal A WanigatungaCenter on Aging and Health, The Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Jennifer A SchrackThe Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland, USA.
Erin D MichosDepartment of Medicine, The Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Christine M MitchellDepartment of Medicine, The Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Rita R KalyaniDepartment of Medicine, The Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Lawrence J AppelDepartment of Medicine, The Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins University · USBeth Israel Deaconess Medical Center · US

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Vitamin D Supplements to Prevent Falls in Older Adults: A Dose-Response TrialU01AG047837 · NIA · JOHNS HOPKINS UNIVERSITY · PI APPEL, LAWRENCE JOHN · 2014 to 2019
$9.5M
Vitamin D, Subclinical Cardiovascular Disease, and Orthostatic Hypotension in Older AdultsK23HL135273 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2017 to 2021
$1.1M
Johns Hopkins Institute for Clinical and Translation Research UL1TR003098Mid-Atlantic Nutrition Obesity Research Center P30DK072488NCATS NIH HHS UL1 TR003098NHLBI NIH HHS 7K23HL135273NHLBI NIH HHS K23 HL135273NIA NIH HHS U01 AG047837NIA NIH HHS U01AG047837NIDDK NIH HHS P30 DK072488
6 · The paper itself

Abstract

backgroundVitamin D3 supplementation is considered a potential intervention to prevent orthostatic hypotension (OH) based on observational evidence that vitamin D levels are inversely associated with OH. With data from The Study to Understand Fall Reduction and Vitamin D in You (STURDY), a double-blind, randomized, response-adaptive trial, we determined if higher doses of vitamin D3 reduced risk of OH.

methodsSTURDY tested the effects of higher (1,000+ IU/day, i.e., 1,000, 2,000, and 4,000 IU/day combined) vs. lower-dose vitamin D3 (200 IU/day, comparison) on fall risk in adults ages 70 years and older with low serum 25-hydroxyvitamin D (25(OH)D, 10-29 ng/ml). OH was determined at baseline, 3, 12, and 24 months by taking the difference between seated and standing blood pressure (BP). OH was defined as a drop in systolic or diastolic BP of at least 20 or 10 mm Hg after 1 minute of standing. Participants were also asked about OH symptoms during the assessment and the preceding month.

resultsAmong 688 participants (mean age 77 [SD, 5] years; 44% women; 18% Black), the mean baseline systolic/diastolic BP was 130 (19)/67 (11) mm Hg, serum 25(OH)D was 22.1 (5.1) ng/ml, and 2.8% had OH. There were 2,136 OH assessments over the maximum 2-year follow-up period. Compared with 200 IU/day, 1,000+ IU/day was not associated with seated, standing, or orthostatic BP, and it did not lower risk of OH or orthostatic symptoms.

conclusionsThese findings do not support use of higher doses of vitamin D3 supplementation as an intervention to prevent OH. CLINICAL TRIALS REGISTRATION: Trial Number NCT02166333.

Indexed as

Hypotension, OrthostaticAdultAgedCholecalciferolDietary SupplementsDouble-Blind MethodFemaleHumansMaleVitamin DVitaminsCholecalciferolVitamin DVitaminsblood pressurehypertensionorthostatic hypotensiontrialvitamin D3

Identifiers

PMID34537827
PMCPMC8807156
OpenAlexW3200674885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.