ArticleNeuroImage2021
Long term effects of cueing procedural memory reactivation during NREM sleep.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Photobiomodulation and sleep quality: systematic review and meta-analysis.Lasers in medical science · 2026Pooled it
- Efficacy and mechanisms of repeated closed-loop auditory exposure during slow-wave sleep for internet gaming disorder.Molecular psychiatry · 2025Trial
- Theta oscillations tag episodic memories for sleep-dependent consolidation.PLoS biology · 2026Article
- Distributed and gradual microstructure changes are associated with the emergence of behavioural benefit from memory reactivation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Optimizing Sleep in Athletes: The Potential of α-Lactalbumin in Nutrition Intervention.Protein and peptide letters · 2025Review
- Article
- Modulating social learning-induced evaluation updating during human sleep.NPJ science of learning · 2024Article
- An update on recent advances in targeted memory reactivation during sleep.NPJ science of learning · 2024Review
- Memory reactivation in slow wave sleep enhances relational learning in humans.Communications biology · 2024Article
- Cueing memory reactivation during NREM sleep engenders long-term plasticity in both brain and behaviour.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Item-specific neural representations during human sleep support long-term memory.PLoS biology · 2023Article
- Article
- Rule Abstraction Is Facilitated by Auditory Cuing in REM Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Presenting rose odor during learning, sleep and retrieval helps to improve memory consolidation: a real-life study.Scientific reports · 2023Article
- Updating memories of unwanted emotions during human sleep.Current biology : CB · 2023Article
- Targeted memory reactivation during sleep can induce forgetting of overlapping memories.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Sleep Quality: A Narrative Review on Nutrition, Stimulants, and Physical Activity as Important Factors.Nutrients · 2022Review
- Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol Dependence.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Targeted memory reactivation (TMR) has recently emerged as a promising tool to manipulate and study the sleeping brain. Although the technique is developing rapidly, only a few studies have examined how the effects of TMR develop over time. Here, we use a bimanual serial reaction time task (SRTT) to investigate whether the difference between the cued and un-cued sequence of button presses persists long-term. We further explore the relationship between the TMR benefit and sleep spindles, as well as their coupling with slow oscillations. Our behavioural analysis shows better performance for the dominant hand. Importantly, there was a strong effect of TMR, with improved performance on the cued sequence after sleep. Closer examination revealed a significant benefit of TMR at 10 days post-encoding, but not 24 h or 6 weeks post-encoding. Time spent in stage 2, but not stage 3, of NREM sleep predicted cueing benefit. We also found a significant increase in spindle density and SO-spindle coupling during the cue period, when compared to the no-cue period. Together, our results demonstrate that TMR effects evolve over several weeks post-cueing, as well as emphasising the importance of stage 2, spindles and the SO-spindle coupling in procedural memory consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.