Evidence map›Paper›PMID 34537379›Full record

ReviewNeurobiology of learning and memory2021

Beyond the hippocampus: The role of parahippocampal-prefrontal communication in context-modulated behavior.

Xiangyuan Peng, Rebecca D Burwell

Abstract readReview
In one paragraph

Review in Neurobiology of learning and memory, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xiangyuan PengDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI 02912, USA.
Rebecca D BurwellDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI 02912, USA; Department of Neuroscience, Brown University, Providence, RI 02912, USA. Electronic address: rebecca_burwell@brown.edu.

Funding

Circuit analysis of corticohippocampal interactions in memoryR01MH108729 · NIMH · BROWN UNIVERSITY · PI BURWELL, REBECCA D. · 2016 to 2020
$2.1M
NIMH NIH HHS R01 MH108729
6 · The paper itself

Abstract

Multiple paradigms indicate that the physical environment can influence spontaneous and learned behavior. In rodents, context-dependent behavior is putatively supported by the prefrontal cortex and the medial temporal lobe. A preponderance of the literature has targeted the role of the hippocampus. In addition to the hippocampus proper, the medial temporal lobe also comprises parahippocampal areas, including the perirhinal and postrhinal cortices. These parahippocampal areas directly connect with multiple regions in the prefrontal cortex. The function of these connections, however, is not well understood. This article first reviews the involvement of the perirhinal, postrhinal, and prefrontal cortices in context-dependent behavior in rodents. Then, based on functional and anatomical evidence, we suggest that perirhinal and postrhinal contributions to context-dependent behavior go beyond supporting context representation in the hippocampus. Specifically, we propose that the perirhinal and postrhinal cortices act as a contextual-support network that directly provides contextual and spatial information to the prefrontal cortex. In turn, the perirhinal and postrhinal cortices modulate prefrontal input to the hippocampus in the service of context-guided behavior.

Indexed as

AnimalsHippocampusHumansLearningNeural PathwaysParahippocampal GyrusPrefrontal CortexRecognition, PsychologyContext memoryHippocampusOccasion settingPerirhinal cortexPostrhinal cortexPrefrontal cortex

Identifiers

PMID34537379
PMCPMC10306268

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.