Evidence map›Paper›PMID 34537236›Full record

ArticleJournal of molecular biology2022

FTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression.

Michael J McFadden, Matthew T Sacco, Kristen A Murphy, Moonhee Park, Nandan S Gokhale, Kim Y Somfleth, Stacy M Horner

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. cGAMP suppresses FTO expression to promote mCellular and molecular life sciences : CMLS · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Insights into the mCell & bioscience · 2024
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. The role of mFrontiers in endocrinology · 2023
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Michael J McFaddenDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: mcfaddmj@umich.edu.
Matthew T SaccoDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: matthew.sacco@duke.edu.
Kristen A MurphyDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: kristen.a.murphy@duke.edu.
Moonhee ParkDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: moonhee.park@duke.edu.
Nandan S GokhaleDepartment of Immunology, University of Washington, Seattle, WA 98109, USA. Electronic address: ngokhale@uw.edu.
Kim Y SomflethDepartment of Immunology, University of Washington, Seattle, WA 98109, USA. Electronic address: ksomf@uw.edu.
Stacy M HornerDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: stacy.horner@duke.edu.
Duke University Hospital · USDuke Medical Center · USUniversity of Washington · US

Funding

Viral Oncology Training GrantT32CA009111 · NCI · DUKE UNIVERSITY · PI LUFTIG, MICAH A. · 1985 to 2023
$8.9M
Defining the role of the RNA modification N6-methyladenosine in the hepatitis C virus lifecycleR01AI125416 · NIAID · DUKE UNIVERSITY · PI Stacy Michelle Horner · 2016 to 2026
$5.5M
TRAINING PROGRAM IN CELL AND MOLECULAR DERMATOLOGYT32AR007197 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAMES TILFORD ELDER, Sunny Y Wong · 1986 to 2026
$4.2M
NCI NIH HHS T32 CA009111NIAID NIH HHS R01 AI125416NIAMS NIH HHS T32 AR007197
6 · The paper itself

Abstract

Signaling initiated by type I interferon (IFN) results in the induction of hundreds of IFN-stimulated genes (ISGs). The type I IFN response is important for antiviral restriction, but aberrant activation of this response can lead to inflammation and autoimmunity. Regulation of this response is incompletely understood. We previously reported that the mRNA modification m

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOGene Expression RegulationInflammationInterferon Type ISTAT3 Transcription FactorGene ExpressionHumansMethyltransferasesRNA, MessengerAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanInterferon Type IMethyltransferasesRNA, MessengerSTAT3 protein, humanSTAT3 Transcription Factorfat mass and obesity-associated (FTO)inflammationinterferon (IFN)interferon-stimulated gene (ISG)N6-methyladenosine (m(6)A)

Identifiers

PMID34537236
PMCPMC8924017
OpenAlexW3200722158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.