Evidence map›Paper›PMID 34537130›Full record

ReviewPET clinics2021

Artificial Intelligence-Based Image Enhancement in PET Imaging: Noise Reduction and Resolution Enhancement.

Juan Liu, Masoud Malekzadeh, Niloufar Mirian, Tzu-An Song, Chi Liu, Joyita Dutta

Abstract readReview
In one paragraph

Review in PET clinics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Patlak-Guided Self-Supervised Learning for Dynamic PET Denoising.IEEE transactions on radiation and plasma medical sciences · 2026
    Article
  3. Review
  4. Article
  5. Article
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  7. Comprehensive review of artifacts in cardiac MRI and their mitigation.The international journal of cardiovascular imaging · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Age Encoded Adversarial Learning for Pediatric CT Segmentation.Bioengineering (Basel, Switzerland) · 2024
    Article
  15. Review
  16. Article
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  18. Article
  19. Article
  20. Deep learning to automate SPECT MPI myocardial reorientation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Juan LiuDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Masoud MalekzadehDepartment of Electrical and Computer Engineering, University of Massachusetts Lowell, 1 University Avenue, Ball 301, Lowell, MA 01854, USA.
Niloufar MirianDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Tzu-An SongDepartment of Electrical and Computer Engineering, University of Massachusetts Lowell, 1 University Avenue, Ball 301, Lowell, MA 01854, USA.
Chi LiuDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. Electronic address: chi.liu@yale.edu.
Joyita DuttaDepartment of Electrical and Computer Engineering, University of Massachusetts Lowell, 1 University Avenue, Ball 301, Lowell, MA 01854, USA; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: dutta.joyita@mgh.harvard.edu.

Funding

Quantitative Low-Dose PET ImagingR01EB025468 · NIBIB · YALE UNIVERSITY · PI CARSON, RICHARD E., LIU, CHI · 2018 to 2022
$3.2M
Longitudinal predictive modeling for tau in Alzheimer's diseaseR01AG072669 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DUTTA, JOYITA · 2021 to 2025
$2.7M
Tau Quantitation in AD with High Resolution MRI and PETK01AG050711 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DUTTA, JOYITA · 2015 to 2019
$650k
Sleep metrics from machine learning for Alzheimer's disease diagnosticsR21AG068890 · NIA · UNIVERSITY OF MASSACHUSETTS LOWELL · PI DUTTA, JOYITA, SAXENA, RICHA · 2020 to 2021
$473k
Super-Resolution Tau PET Imaging for Alzheimer's DiseaseR03AG070750 · NIA · UNIVERSITY OF MASSACHUSETTS LOWELL · PI DUTTA, JOYITA · 2021 to 2022
$304k
NIA NIH HHS K01 AG050711NIA NIH HHS R01 AG072669NIA NIH HHS R03 AG070750NIA NIH HHS R21 AG068890NIBIB NIH HHS R01 EB025468
6 · The paper itself

Abstract

High noise and low spatial resolution are two key confounding factors that limit the qualitative and quantitative accuracy of PET images. Artificial intelligence models for image denoising and deblurring are becoming increasingly popular for the postreconstruction enhancement of PET images. We present a detailed review of recent efforts for artificial intelligence-based PET image enhancement with a focus on network architectures, data types, loss functions, and evaluation metrics. We also highlight emerging areas in this field that are quickly gaining popularity, identify barriers to large-scale adoption of artificial intelligence models for PET image enhancement, and discuss future directions.

Indexed as

Artificial IntelligenceImage Processing, Computer-AssistedHumansImage EnhancementPositron-Emission TomographySignal-To-Noise RatioArtificial intelligenceDeblurringDeep learningDenoisingPETSuper-resolution

Identifiers

PMID34537130
PMCPMC8457531

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.