Trial reportBrazilian journal of anesthesiology (Elsevier)
Analgesic effect of magnesium sulfate during total intravenous anesthesia: randomized clinical study.
Trial report in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Propofol-esketamine versus propofol-fentanyl combinations for sedation in pediatric flexible fiberoptic bronchoscopy: a randomized controlled trial.BMC anesthesiology · 2025Trial
- Influence of magnesium sulfate on the pharmacodynamic characteristics of rocuronium. A randomized clinical trial.Anaesthesiology intensive therapy · 2025Trial
- Effect ofDrug design, development and therapy · 2024Trial
- Intraoperative magnesium sulphate as an analgesic adjunct in a multimodal, opioid-sparing protocol for canine ovariohysterectomy: a prospective, randomized, controlled, double-blind study.Frontiers in veterinary science · 2026Article
- Magnesium Sulfate as an Analgesic and Sedative-sparing Agent in Patients under Mechanical Ventilation: A Randomized, Double Blind Clinical Trial.Journal of research in pharmacy practice · 2026Article
- Optimal Dose of Magnesium Sulfate Infusion in Obese Patients: A Double-Blind Randomized Trial.Anesthesiology research and practice · 2025Article
- Innovations in Pain Management for Abdominoplasty Patients: A Systematic Review.Journal of personalized medicine · 2024Review
- Intraoperative magnesium sulfate is not associated with improved pain control after urologic procedures.Perioperative medicine (London, England) · 2024Article
- Enhanced recovery after elective spinal surgery: an Australian pilot study.Journal of spine surgery (Hong Kong) · 2024Article
- Review
- Intraoperative Analgesia with Magnesium Sulfate versus Remifentanil Guided by Plethysmographic Stress Index in Post-Bariatric Dermolipectomy: A Randomized Study.Anesthesiology research and practice · 2022Article
- Magnesium: the underestimated ion.Brazilian journal of anesthesiology (Elsevier)Article
- Perioperative analgesia in the elderly.Saudi journal of anaesthesiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
INTRODUCTION AND
objectiveOpioids have usually been used as intraoperative analgesic components, regardless of the many adverse effects they are associated with, such as nausea, vomiting, respiratory depression, and hyperalgesia. Several approaches have been investigated to reduce doses used, and magnesium sulfate has been shown to be a valuable analgesic adjunct. The main objective of the present trial was to evaluate the effectiveness of magnesium sulfate as the chief intraoperative analgesic, and the secondary objectives were to assess propofol consumption, postoperative analgesia, and intraoperative hemodynamic stability.
methodsIn this prospective, double-blind trial, 50 patients scheduled to undergo post-bariatric abdominoplasty under general intravenous anesthesia were divided into two groups, to receive remifentanil or magnesium sulfate as intraoperative analgesic. Fentanyl 1 µg kg
resultsAmong the patients in the group receiving Magnesium Sulfate (MSG), 64% did not need supplemental analgesia and none of the patients in the Remifentanil Group (RG) required fentanyl. MSG patients showed propofol consumption 36.6% higher (guided by the Bispectral Index - BIS). MSG patients consumed significantly less ephedrine (mean ± SD) than RG patients, respectively 1.52 ± 4.38 mg and 10 ± 10.39 mg, p < 0.001. Mean values of blood concentrations of magnesium were comparable to values previously described in the literature.
conclusionMagnesium sulfate is a safe and effective option for intraoperative analgesia, when avoiding or decreasing opioid use is required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.