Evidence map›Paper›PMID 34537067›Full record

ArticlePatient safety in surgery2021

The incidence of acute myocardial infarction after elective spinal fusions or joint replacement surgery in the United States: a large-scale retrospective observational cohort study in 322,585 patients : Post-surgical myocardial infarction data.

Patrick J Arena, Jingping Mo, Qing Liu, Xiaofeng Zhou, Richard Gong, Charles Wentworth, Sundaresan Murugesan, Kui Huang

Open access · goldAbstract read
In one paragraph

Article in Patient safety in surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Patrick J ArenaGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc., 235 E 42nd St, New York, NY, 10017, USA.
Jingping MoSafety Surveillance Research, Pfizer Inc., New York, NY, USA.
Qing LiuGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc., Collegeville, PA, USA.
Xiaofeng ZhouGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc., 235 E 42nd St, New York, NY, 10017, USA.
Richard GongReal World Evidence Center of Excellence, Pfizer Inc., New York, NY, USA.
Charles WentworthGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc., 235 E 42nd St, New York, NY, 10017, USA.
Sundaresan MurugesanReal World Evidence Center of Excellence, Pfizer Inc., New York, NY, USA.
Kui HuangGlobal Medical Epidemiology & Big Data Analysis, Pfizer Inc., 235 E 42nd St, New York, NY, 10017, USA. Kui.A.Huang@pfizer.com.
Pfizer (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute myocardial infarction (AMI) is an uncommon but fatal complication among patients undergoing elective spinal fusion surgery (SF), total hip arthroplasty (THA), and total knee arthroplasty (TKA). Our objective was to estimate the incidence of AMI among adults undergoing elective SF, THA, and TKA in different post-operative risk windows and characterize high-risk sub-populations in the United States.

methodsA retrospective cohort study was conducted using data from a longitudinal electronic healthcare record (EHR) database from January 1, 2007 to June 30, 2018. ICD codes were used to identify SF, THA, TKA, AMI, and selected clinical characteristics. Incidence proportions (IPs) and 95% confidence intervals were estimated in the following risk windows: index hospitalization, ≤ 30, ≤ 90, ≤ 180, and ≤ 365 days post-operation.

resultsA total of 67,533 SF patients, 87,572 THA patients, and 167,480 TKA patients were eligible for the study. The IP of AMI after SF, THA, and TKA ranged from 0.36, 0.28, and 0.25% during index hospitalization to 1.05, 0.93, and 0.85% ≤ 365 days post-operation, respectively. The IP of AMI was higher among patients who were older, male, with longer hospital stays, had a history of AMI, and had a history of diabetes.

conclusionThe IP of post-operative AMI was generally highest among the SF cohort compared to the THA and TKA cohorts. Additionally, potential high-risk populations were identified. Future studies in this area are warranted to confirm these findings via improved confounder control and to identify effect measure modifiers.

Indexed as

Electronic healthcare recordsEpidemiologyMyocardial infarctionSpinal fusionTotal hip arthroplastyTotal knee arthroplasty

Identifiers

PMID34537067
PMCPMC8449870
OpenAlexW3199948026

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.