ArticleReproductive biology and endocrinology : RB&E2021
Higher preconceptional maternal body mass index is associated with faster early preimplantation embryonic development: the Rotterdam periconception cohort.
Article in Reproductive biology and endocrinology : RB&E, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Periconceptional biomarkers for maternal obesity: a systematic review.Reviews in endocrine & metabolic disorders · 2023Pooled it
- A preconception lifestyle intervention in women with obesity and cardiovascular health in their children.Pediatric research · 2023Trial
- A multi-model study of the association between BMI and AMH in Chinese women.Endocrine connections · 2026Article
- Lower oxidative balance score is linked to increased miscarriage risk: findings from a case-control study.BMC pregnancy and childbirth · 2026Article
- Spontaneous Pregravid Obesity Reshapes Fetal Immune Ontogeny in a Nonhuman Primate Model.bioRxiv : the preprint server for biology · 2026Article
- Association between laser-assisted hatching and subsequent blastocyst development in fresh day 3 cleavage-stage embryos: a retrospective cohort study using propensity score matching, generalized estimating equations, and time-sensitivity analyses.Frontiers in endocrinology · 2026Article
- Maternal serum progesterone and BMI are associated with neonatal sex ratios following single frozen embryo transfer.PloS one · 2026Article
- Parental dietary patterns and assisted reproductive technology outcomes including embryo morphokinetics: rotterdam periconception cohort.Journal of assisted reproduction and genetics · 2025Article
- Adverse effects of maternal and paternal body mass index on assisted reproductive techniques outcomes: A time-lapse study.Clinical and experimental reproductive medicine · 2025Article
- Metabolic reprogramming of fetal hematopoietic stem and progenitor cells by maternal obesity.Frontiers in hematology · 2025Article
- Preconception and Early-Pregnancy Body Mass Index in Women and Men, Time to Pregnancy, and Risk of Miscarriage.JAMA network open · 2024Article
- Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity.Science China. Life sciences · 2024Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundOverweight and obesity affect millions of people globally, which has also serious implications for reproduction. For example, treatment outcomes after in vitro fertilisation (IVF) are worse in women with a high body mass index (BMI). However, the impact of maternal BMI on embryo quality is inconclusive. Our main aim is to study associations between preconceptional maternal BMI and morphokinetic parameters of preimplantation embryos and predicted implantation potential. In addition, associations with clinical IVF outcomes are investigated.
methodsFrom a tertiary hospital, 268 women undergoing IVF or IVF with intracytoplasmic sperm injection (ICSI) were included; 143 normal weight, 79 overweight and 46 obese women. The embryos of these women were cultured in the EmbryoScope, a time-lapse incubator. The morphokinetic parameters of preimplantation embryos and predicted implantation potential, assessed by the KIDScore algorithm were longitudinally evaluated as primary and secondary outcomes, respectively. The tertiary outcomes included clinical outcomes, i.e., fertilization, implantation and live birth rate.
resultsAfter adjustment for patient- and treatment-related factors, we demonstrated in 938 embryos that maternal BMI is negatively associated with the moment of pronuclear appearance (β
conclusionsHigher maternal BMI is associated with faster early preimplantation development. In couples with female or combined factor subfertility, a higher BMI is associated with a lower implantation potential as predicted by the KIDScore. Likely due to power issues, we did not observe an impact on clinical treatment outcomes. However, an effect of faster preimplantation development on post-implantation development is conceivable, especially since the impact of maternal BMI on pregnancy outcomes has been widely demonstrated.
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