Evidence map›Paper›PMID 34537063›Full record

ArticleArthritis research & therapy2021

Risk of rheumatoid arthritis diagnosis in statin users in a large nationwide US study.

Madeline N Peterson, Hayley J Dykhoff, Cynthia S Crowson, John M Davis, Lindsey R Sangaralingham, Elena Myasoedova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madeline N PetersonDivision of Rheumatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Hayley J DykhoffRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Cynthia S CrowsonDivision of Rheumatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
John M DavisDivision of Rheumatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Lindsey R SangaralinghamRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Elena MyasoedovaDivision of Rheumatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. myasoedova.elena@mayo.edu.

Funding

HEART DISEASE IN RHEUMATOID ARTHRITISR01AR046849 · NIAMS · MAYO CLINIC ROCHESTER · PI CROWSON, CYNTHIA S · 2000 to 2022
$11.3M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Role of Systemic Inflammation in Cognitive Decline: Rheumatoid Arthritis as a PrototypeR01AG068192 · NIA · MAYO CLINIC ROCHESTER · PI Elena Myasoedova · 2020 to 2026
$4.4M
NIAMS NIH HHS R01 AR046849NIAMS NIH HHS R01 AR46849NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG068192
6 · The paper itself

Abstract

objectiveTo evaluate the association between statin use and the risk of developing rheumatoid arthritis (RA) in a large, US case-control study.

methodsUsing the OptumLabs Data Warehouse, RA cases were identified as patients aged ≥18 years with ≥2 RA diagnoses between January 1, 2010 and June 30, 2019 and ≥1 prescription fills for methotrexate within 1 year of the first RA diagnosis. The first RA diagnosis was the index date. Cases were matched 1:1 to controls on age, sex, region, year of index date, and length of baseline coverage. Statin users were defined by having ≥2 statin prescription fills at least 90 days pre-index. Patients identified as statin users were further classified by statin user status (current or former), statin use duration, and intensity of statin exposure. Odds ratios for RA risk with statin use were estimated using logistic regression.

results16,363 RA cases and 16,363 matched controls were identified. Among RA cases, 5509 (33.7%) patients were statin users compared to 5164 (31.6%) of the controls. Statin users had a slightly increased risk of RA compared to non-users (OR 1.12, 95% CI 1.06-1.18), and former statin users had an increased RA risk compared to current users (OR 1.21, 95% CI 1.13-1.28). However, risk was eliminated following adjustment for hyperlipidemia. The risk estimates for statin use duration and intensity did not reach significance.

conclusionThis study demonstrates no significant increase in the risk of developing RA for statin users compared to non-users after adjustment for hyperlipidemia in addition to other relevant confounders. However, more information from prospective studies would be necessary to further understand this relationship.

Indexed as

Arthritis, RheumatoidHydroxymethylglutaryl-CoA Reductase InhibitorsAdolescentAdultCase-Control StudiesHumansOdds RatioProspective StudiesRisk FactorsHydroxymethylglutaryl-CoA Reductase InhibitorsLipid-lowering medicationsRheumatoid arthritisRisk factors

Identifiers

PMID34537063
PMCPMC8449497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.