ArticleBMC neurology2021
The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy.
Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- EANM practice guidelines for an appropriate use of PET and SPECT for patients with epilepsy.European journal of nuclear medicine and molecular imaging · 2024Guideline
- Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives.Frontiers in neurology · 2022Pooled it
- Lateralization of FDG-PET Hypometabolism Using Resting-State fMRI in Temporal Lobe Epilepsy: A Simultaneous PET-MRI Study.Tomography (Ann Arbor, Mich.) · 2026Article
- Pediatric Epilepsy Surgery: The Noninvasive Presurgical Evaluation.Pediatric neurosurgery · 2026Review
- Comparison of Magnetic Resonance Spectra Acquired With Hybrid PET/MR and Standalone MR Scanners.Journal of magnetic resonance imaging : JMRI · 2025Article
- The Role of the Sentence Constraint in New Word Acquisition While Reading in Adolescents: The ERP N400 and P600 and Reading-Related Skills.Brain sciences · 2025Article
- Quantitative Cortex-Based Mapping With HybridCNS neuroscience & therapeutics · 2025Article
- Long-term trends in total administered radiation dose from brain [European journal of nuclear medicine and molecular imaging · 2025Article
- Clinical features of 21 cases of drug-resistant epilepsy and the therapeutic effect of stereotactic electroencephalography guided epileptic foci resection.American journal of translational research · 2024Article
- An Assessment of the Pathological Classification and Postoperative Outcome of Focal Cortical Dysplasia by Simultaneous Hybrid PET/MRI.Brain sciences · 2023Article
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Authors and funding
26 authors.
Funding
Abstract
backgroundWhen MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20-65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients.
methodsIn a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI.
resultsThe hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the original lesion was confirmed by means of hybrid FDG-PET/MRI. As to the therapeutic decision-making, these results helped to indicate resective surgery instead of intracranial EEG (iEEG) monitoring in 2 cases, to avoid any further invasive diagnostic procedures in 7 patients, and to refer 21 patients for iEEG in the nonlesional group. Hybrid FDG-PET/MRI has also significantly changed the original therapeutic plans in the lesional group. Prior to the hybrid imaging, a resective surgery was considered in 3 patients, and iEEG was planned in 27 patients. However, 3 patients became eligible for resective surgery, 6 patients proved to be inoperable instead of iEEG, and 18 cases remained candidates for iEEG due to the hybrid FDG-PET/MRI. Two patients remained candidates for resective surgery and one patient became not eligible for any further invasive intervention.
conclusionsThe results of hybrid FDG-PET/MRI significantly altered the original plans in 19 of 60 cases. The introduction of hybrid FDG-PET/MRI into the presurgical evaluation process had a potential modifying effect on clinical decision-making.
trial registrationTrial registry: Scientific Research Ethics Committee of the Medical Research Council of Hungary. TRIAL REGISTRATION NUMBER: 008899/2016/OTIG . Date of registration: 08 February 2016.
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