ArticleContemporary clinical trials2021
A SMART approach to optimizing delivery of an mHealth intervention among cancer survivors with posttraumatic stress symptoms.
Article in Contemporary clinical trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Adaptive, Stepped-Care for Cancer-Related PTSD Symptoms in HCT Survivors: Results From a SMART Trial.Psycho-oncology · 2026Trial
- A Pilot Study of the Cancer Distress Coach-Caregiver App: A Digital Intervention for Reducing PTSD Symptoms in HCT Caregivers.Psycho-oncology · 2025Trial
- Assessing the utility of the PC-PTSD-5 as a screening tool among a cancer survivor sample.Cancer · 2024Trial
- Improving well-being for individuals with persistent pain after surgery for breast cancer, lobular carcinoma in situ, or ductal carcinoma in situ: A randomized clinical trial.Contemporary clinical trials · 2022Trial
- Observational
- A review of use of external data and update on reporting standards in Sequential Multiple-Assignment Randomised Trials.Clinical trials (London, England) · 2026Review
- Empowering Cancer Patients: A Scoping Review on Gamified Approaches To Health Literacy for Self-Care.Journal of medical systems · 2025Article
- Reducing the burden of PTSD through digital interventions and development of sequential precision treatment rules.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Mobile cognitive behavioral therapy for posttraumatic stress: Diving back in after hematopoietic stem cell transplant.Psycho-oncology · 2022Article
- Enhancing Mental Resilience Among Frontline Nurses Post-COVID-19: A Non-Randomized Study of mHealth-Based Group Coping Skills Training.SAGE open nursingArticle
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsMany cancer survivors who received intensive treatment such as hematopoietic stem cell transplantation (HCT) experience posttraumatic stress disorder (PTSD) symptoms. PTSD is associated with lower quality of life and other symptoms that require clinical treatment. The iterative treatment decisions that happen in clinical practice are not adequately represented in traditional randomized controlled trials (RCT) of PTSD treatments. The proposed stepped-care SMART design allows for evaluation of initial response to the Cancer Distress Coach mobile app; adaptive stepped-care interventions; and precision treatment strategies that tailor treatment selection to patient characteristics. METHODS/
designHCT survivors (N = 400) reporting PTSD symptoms are being recruited at two cancer centers and randomly assigned to: 1) Cancer Distress Coach app or 2) Usual Care. The app includes educational and cognitive behavioral therapy (CBT)-based activities. Four weeks post-randomization, participants re-rate their PTSD symptoms and, based on intervention response, non-responders are re-randomized to receive video-conferenced sessions with a therapist: 3) coaching sessions in using the mobile app; or 4) CBT specific to HCT survivors. Participants complete outcome measures of PTSD, depression, and anxiety after Months 1, 3, and 6. Participant characteristics moderating intervention responses will be examined.
conclusionsThis novel adaptive trial design will afford evidence that furthers knowledge about optimizing PTSD interventions for HCT survivors. To our knowledge, this study is the first SMART design evaluating PTSD symptom management in cancer survivors. If successful, it could be used to optimize treatment among a range of cancer and other trauma survivors.
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