ArticleThe Journal of allergy and clinical immunology2022
Neuroimaging and biomarker evidence of neurodegeneration in asthma.
Article in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Unknotting the nexus of asthma and neuroinflammation: from brain network alterations to therapeutic implications.Journal of neuroinflammation · 2026Review
- Association between asthma and changes in brain cortical structure: a Mendelian randomization study.BMC pulmonary medicine · 2026Article
- Acupuncture for Persistent Asthma: Protocol for a Randomized, Sham-Controlled Trial with Neuroimaging.Journal of asthma and allergy · 2026Article
- Global Trends of Cognition-Targeted Interventions in Chronic Lung Disease: A Bibliometric and Visualized Analysis.International journal of chronic obstructive pulmonary disease · 2026Review
- IL7RBrain and behavior · 2025Article
- The immunology of asthma and chronic rhinosinusitis.Nature reviews. Immunology · 2025Review
- Regional brain structural alterations in reward and salience networks in asthma.Brain, behavior, and immunity · 2025Article
- The therapeutic potential of glucagon-like peptide-1 receptor analogs for neuroinflammation in the setting of asthma.Exploration of asthma & allergy · 2025Article
- Associations of serum neurofilament and asthma: evidence from the NHANES 2013-2014.Frontiers in neurology · 2025Article
- Asthma as a Modifiable Risk Factor for Dementia and Neurodegeneration: A Systematic Review.Cureus · 2025Review
- Asthma and cognitive dysfunction in older adults: the mediating role of systemic immune-inflammation index.Scientific reports · 2024Article
- Asthma and Memory Function in Children.JAMA network open · 2024Observational
- Alzheimer incidence and prevalence with and without asthma: A Medicare cohort study.The Journal of allergy and clinical immunology · 2024Article
- Systemic Inflammation in Asthma: What Are the Risks and Impacts Outside the Airway?The journal of allergy and clinical immunology. In practice · 2024Review
- Examining the Biopsychosocial Factors Related to Lifetime History of Concussion in Children and Youth.Child psychiatry and human development · 2024Article
- Association of Plasma Claudin-5 with Age and Alzheimer Disease.International journal of molecular sciences · 2024Article
- Potential association between obstructive lung diseases and cognitive decline.Frontiers in immunology · 2024Observational
- Response to: Failure of the glymphatic system by increases of jugular resistance as possible link between asthma and dementia.Brain communications · 2024Article
- Failure of the glymphatic system by increases of jugular resistance as possible link between asthma and dementia.Brain communications · 2024Article
- Functional connectivity alterations in the thalamus among patients with bronchial asthma.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundEpidemiologic studies have shown that Alzheimer's disease (AD) and related dementias (ADRD) are seen more frequently with asthma, especially with greater asthma severity or exacerbation frequency.
objectiveTo examine the changes in brain structure that may underlie this phenomenon, we examined diffusion-weighted magnetic resonance imaging (dMRI) and blood-based biomarkers of AD (phosphorylated tau 181, p-Tau181), neurodegeneration (neurofilament light chain, NfL), and glial activation (glial fibrillary acidic protein, GFAP).
methodsdMRI data were obtained in 111 individuals with asthma, ranging in disease severity from mild to severe, and 135 healthy controls. Regression analyses were used to test the relationships between asthma severity and neuroimaging measures, as well as AD pathology, neurodegeneration, and glial activation, indexed by plasma p-Tau181, NfL, and GFAP, respectively. Additional relationships were tested with cognitive function.
resultsAsthma participants had widespread and large-magnitude differences in several dMRI metrics, which were indicative of neuroinflammation and neurodegeneration, and which were robustly associated with GFAP and, to a lesser extent, NfL. The AD biomarker p-Tau181 was only minimally associated with neuroimaging outcomes. Further, asthma severity was associated with deleterious changes in neuroimaging outcomes, which in turn were associated with slower processing speed, a test of cognitive performance.
conclusionsAsthma, particularly when severe, is associated with characteristics of neuroinflammation and neurodegeneration, and may be a potential risk factor for neural injury and cognitive dysfunction. There is a need to determine how asthma may affect brain health and whether treatment directed toward characteristics of asthma associated with these risks can mitigate these effects.
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