ArticleThe Journal of allergy and clinical immunology2021
Multiethnic genome-wide and HLA association study of total serum IgE level.
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Article in The Journal of allergy and clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17citing papers in PubMed, 2 pooled it
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Meta-regression of genome-wide association studies to estimate age-varying genetic effects.European journal of epidemiology · 2024Pooled it
- Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria.Communications biology · 2023Pooled it
- Multitrait analysis of genome-wide association studies expands eosinophilic esophagitis genetic susceptibility and polygenic risk scores.The Journal of allergy and clinical immunology · 2026Article
- Associations between genetic ancestry and allergic outcomes at 10 years among Black children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Prevalence of allergic diseases and evaluation of total IgE and blood eosinophils as diagnostic biomarkers in Colombia, a tropical country.The World Allergy Organization journal · 2026Article
- Allergic phenotypes and asthma in multiple sclerosis: Epidemiologic and genetic relationships.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Genome-Wide Cross-Trait Analysis in European Populations Reveals Shared Genetic Architecture of Chronic Obstructive Pulmonary Disease and the Allergy Spectrum.International archives of allergy and immunology · 2025Article
- Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study.American journal of human genetics · 2025Article
- Genetic and Immunological Pathogenesis of Atopic Dermatitis.The Journal of investigative dermatology · 2024Review
- Review
- Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease.The Journal of experimental medicine · 2023Article
- Novel insights into atopic dermatitis.The Journal of allergy and clinical immunology · 2023Review
- Targeted capture enrichment and sequencing identifies HLA variants associated with the severity of COVID-19.Genes & genomics · 2023Article
- Recent progress in the genetic and epigenetic underpinnings of atopy.The Journal of allergy and clinical immunology · 2023Review
- Race/ethnicity-stratified fine-mapping of the MHC locus reveals genetic variants associated with late-onset asthma.Frontiers in genetics · 2023Article
- Genetic Determinants in Airways Obstructive Diseases: The Case of Asthma Chronic Obstructive Pulmonary Disease Overlap.Immunology and allergy clinics of North America · 2022Review
- Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank.BMC medical genomics · 2022Article
Corrections and comments
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Authors and funding
48 authors at 20 institutions in 5 countries.
Michelle DayaDepartment of Medicine, University of Colorado, Aurora, Colo.
Corey CoxDepartment of Medicine, University of Colorado, Aurora, Colo.
Nathalie AcevedoInstitute for Immunological Research, University of Cartagena, Cartagena, Colombia.
Meher P BoorgulaDepartment of Medicine, University of Colorado, Aurora, Colo.
Monica CampbellDepartment of Medicine, University of Colorado, Aurora, Colo.
Sameer ChavanDepartment of Medicine, University of Colorado, Aurora, Colo.
Michael H ChoChanning Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Gloria L DavidRho, Inc, Durham.
Priyadarshini KachrooChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Jessica Lasky-SuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Xingnan LiDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Ariz.
Caitlin P McHughDepartment of Biostatistics, University of Washington, Seattle, Wash.
Dandi QiaoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Nicholas RafaelsDepartment of Medicine, University of Colorado, Aurora, Colo.
Lisa A BeckUniversity of Rochester Medical Center, Rochester, NY.
Eugene R BleeckerDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Ariz.
Luis CaraballoInstitute for Immunological Research, University of Cartagena, Cartagena, Colombia.
Adrienne L CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, Mass.
Camila A FigueiredoInstituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Richard L GalloUniversity of California San Diego, San Diego, Calif.
Jon HanifinOregon Health & Science University, Portland, Ore.
Nadia N HanselPulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Md.
Tissa R HataUniversity of California San Diego, San Diego, Calif.
Craig P HershChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Jennifer Knight-MaddenCaribbean Institute for Health Research, The University of the West Indies Kingston, Kingston, Jamaica.
Donald Y M LeungDivision of Pediatric Allergy & Immunology, National Jewish Health, Denver, Colo.
Emma Guttman-YasskyIcahn School of Medicine at Mount Sinai, New York, NY.
Deborah A MeyersDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Ariz.
George O'ConnorDepartment of Medicine, Boston University School of Medicine, Boston, Mass.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, Ill.
Peck Y OngDivision of Clinical Immunology and Allergy, Children's Hospital Los Angeles and University of Southern California, Los Angeles, Calif.
Victor E OrtegaDepartment of Internal Medcinie, Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Amy S PallerNorthwestern University and Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Nirupama PutchaPulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Md.
Robert M ReedUniversity of Maryland School of Medicine, Baltimore, Md.
Lynda C SchneiderBoston Children's Hospital and Harvard Medical School.
Edwin K SilvermanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Mark K SlifkaOregon Health & Science University, Portland, Ore.
Jonathan M SpergelDepartment of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pa.
Ramachandran S VasanDepartment of Medicine, Boston University Schools of Medicine and Public Health, Boston, Mass; Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Mass.
Karine A Viaud-MartinezIllumina Laboratory Services, Illumina, Inc, San Diego, Calif.
Harold WatsonFaculty of Medical Sciences, The University of the West Indies, Queen Elizabeth Hospital, Bridgetown, St. Michael, Barbados.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Ingo RuczinskiDepartment of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md.
Terri H BeatyDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md.
Rasika A MathiasDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md.
Kathleen C BarnesDepartment of Medicine, University of Colorado, Aurora, Colo. Electronic address: Kathleen.Barnes@cuanschutz.edu.
Brigham and Women's Hospital · USUniversity of Colorado Anschutz Medical Campus · USJohns Hopkins University · USBoston University · USUniversity of Arizona · USOregon Health & Science University · USUniversity of California San Diego · USUniversity of Cartagena · COBoston Children's Hospital · USIcahn School of Medicine at Mount Sinai · USIllumina (United States) · USLurie Children's Hospital · USNational Jewish Health · USUniversidade Federal da Bahia · BRUniversity of Chicago · USUniversity of Maryland, Baltimore · USUniversity of Pennsylvania · USUniversity of Rochester Medical Center · USUniversity of Southern California · USUniversity of the West Indies · JM
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MTransplantation GroupUM2AI117870 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI DAVID, GLORIA · 2015 to 2023
$208.1MNHLBI Data Stage Coordinating CenterOT3HL147154 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ashok Kumar Krishnamurthy · 2018 to 2026
$98.9MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MTargeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI LEUNG, DONALD YM · 2015 to 2019
$30.6MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MThe Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data CommonsOT3HL142481 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI GROSSMAN, ROBERT L., PATEN, BENEDICT · 2017 to 2020
$24.9MNew Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MThe Genetic Epidemiology of Asthma in Costa RicaR37HL066289 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2015
$14.6MThe Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data CommonsOT3HL142478 · NHLBI · SEVEN BRIDGES GENOMICS, INC. · PI DAVIS-DUSENBERY, BRANDI NICOLE · 2017 to 2022
$12.6MNHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201500016CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS OT3 HL142478NHLBI NIH HHS OT3 HL142479NHLBI NIH HHS OT3 HL142480NHLBI NIH HHS OT3 HL142481NHLBI NIH HHS OT3 HL147154NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL087699NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL121007NHLBI NIH HHS R01 HL130512NHLBI NIH HHS R37 HL066289NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL120393NIAID NIH HHS R01 AI114555NIAID NIH HHS R01 AI132476NIAID NIH HHS U19 AI117673NIAID NIH HHS UM2 AI117870NIA NIH HHS R01 AG018728
Abstract
backgroundTotal serum IgE (tIgE) is an important intermediate phenotype of allergic disease. Whole genome genetic association studies across ancestries may identify important determinants of IgE.
objectiveWe aimed to increase understanding of genetic variants affecting tIgE production across the ancestry and allergic disease spectrum by leveraging data from the National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine program; the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA); and the Atopic Dermatitis Research Network (N = 21,901).
methodsWe performed genome-wide association within strata of study, disease, and ancestry groups, and we combined results via a meta-regression approach that models heterogeneity attributable to ancestry. We also tested for association between HLA alleles called from whole genome sequence data and tIgE, assessing replication of associations in HLA alleles called from genotype array data.
resultsWe identified 6 loci at genome-wide significance (P < 5 × 10
conclusionWe performed the largest genome-wide association study and HLA association study of tIgE focused on ancestrally diverse populations and found several known tIgE and allergic disease loci that are relevant in non-European ancestry populations.
Indexed as
EthnicityGenotypeAdolescentAdultAgedAsthmaChildChild, PreschoolDermatitis, AtopicFemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHLA-A2 AntigenHLA-DQ beta-ChainsHumansHLA-A*02:01 antigenHLA-A2 AntigenHLA-DQB1 antigenHLA-DQ beta-ChainsImmunoglobulin Easthmaatopic dermatitisgenome-wide association studyhuman leukocyte antigenmultiethnicTotal serum IgE
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