ArticleJournal of the American Geriatrics Society2022
Life expectancy estimates based on comorbidities and frailty to inform preventive care.
Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Frailty carries an increased risk of death in rheumatoid arthritis.Seminars in arthritis and rheumatism · 2025Article
- Older adults' interest and concerns about life expectancy information for cancer screening decisions: Results from the National Poll on Healthy Aging.Preventive medicine reports · 2025Article
- Potential gains from radical treatment of men with prostate cancer according to life expectancy.BJUI compass · 2025Article
- External validation of a proprietary risk model for 1-year mortality in community-dwelling adults aged 65 years or older.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Managing Hypercholesterolemia in Adults Older Than 75 years Without a History of Atherosclerotic Cardiovascular Disease: An Expert Clinical Consensus From the National Lipid Association and the American Geriatrics Society.Journal of the American Geriatrics Society · 2025Article
- Life expectancy of patients with early gastric cancer who underwent curative gastrectomy: comparison with the general population.Scientific reports · 2025Article
- Impact of age and comorbidities on colorectal endoscopic submucosal dissection outcomes: Large multicenter study in a Western cohort.Endoscopy international open · 2025Article
- Does 23-Valent Pneumococcal Polysaccharide Vaccination Decrease All-Cause Mortality?Open forum infectious diseases · 2024Article
- AI Survival Prediction Modeling: The Importance of Considering Treatments and Changes in Health Status over Time.Cancers · 2024Article
- Frailty in Older Adults.The New England journal of medicine · 2024Review
- Comparison of Claims-Based Frailty Indices in U.S. Veterans 65 and Older for Prediction of Long-Term Institutionalization and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Risk assessment in pulmonary arterial hypertension patients with multiple comorbidities and/or advanced age-Where do we stand and what's next?Pulmonary circulation · 2023Article
- Preoperative frailty and adverse outcomes following coronary artery bypass grafting surgery in US veterans.Journal of the American Geriatrics Society · 2023Article
- Frailty predicts referral for elder abuse evaluation in a nationwide healthcare system-Results from a case-control study.Journal of the American Geriatrics Society · 2023Article
- Early or Late-Life Treatment With Acarbose or Rapamycin Improves Physical Performance and Affects Cardiac Structure in Aging Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients: An Observational Study.Medicina (Kaunas, Lithuania) · 2023Observational
- Predictive validity of the Short Functional Geriatric Evaluation for mortality, hospitalization and institutionalization in older adults: A retrospective cohort survey.International journal of nursing sciences · 2023Article
- COVID-19 infection and decline in outdoor activities associated with depression in older adults: A multicenter study in Vietnam.PloS one · 2023Article
- Medium and long-term prognosis in hospitalised older adults with multimorbidity. A prospective cohort study.PloS one · 2023Article
- Comparing the association between multiple chronic conditions, multimorbidity, frailty, and survival among older patients with cancer.Journal of geriatric oncology · 2022Article
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Funding
Abstract
backgroundLong-term prognostication is important to inform preventive care in older adults. Existing prediction indices incorporate age and comorbidities. Frailty is another important factor in prognostication. In this project, we aimed at developing life expectancy estimates that incorporate both comorbidities and frailty.
methodsIn this retrospective cohort study, we used data from a 5% sample of Medicare beneficiaries with and without history of cancer from Surveillance, Epidemiology, and End Results (SEER) cancer registry areas. We included adults aged 66-95 years who were continuously enrolled in fee-for-service Medicare for ≥1 year from 1998 to 2014. Participants were followed for survival until 12/31/2015, death, or disenrollment. Comorbidity (none, low/medium, high) and frailty categories (low, high) were defined using established methods for claims. We estimated 5- and 10-year survival probabilities and median life expectancies by age, sex, comorbidities, and frailty.
resultsThe study included 479,646 individuals (4,128,316 person-years), of whom most were women (58.7%). Frailty scores varied widely among participants in the same comorbidity category. In Cox models, both comorbidities and frailty were independent predictors of mortality. Individuals with high comorbidities (HR, 3.24; 95% CI, 3.20-3.28) and low/medium comorbidities (HR, 1.36; 95% CI, 1.34-1.39) had higher risks of death than those with no comorbidities. Compared to low frailty, high frailty was associated with higher risk of death (HR, 1.55; 95% CI, 1.52-1.58). Frailty affected life expectancy estimates in ways relevant to preventive care (i.e., distinguishing <10-year versus >10-year life expectancy) in multiple subgroups.
conclusionIncorporating both comorbidities and frailty may be important in estimating long-term life expectancies of older adults. Our life expectancy tables can aid clinicians' prognostication and inform simulation models and population health management.
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