ArticleAnnals of neurology2021
Relation of Pre-Stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes.
Article in Annals of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Annual Trends in Risk Factor Control Status at the Time of Ischemic Stroke in South Korea.Journal of the American Heart Association · 2026Article
- Prehospital aspirin use is associated with improved clinical outcomes in pulmonary embolism: A retrospective case-control study.World journal of cardiology · 2025Article
- Multicenter Validation of Artificial Intelligence Predicting Anterior Circulation Large Vessel Occlusion Using Noncontrast Head CT.Stroke (Hoboken, N.J.) · 2025Article
- Segmentation of Leukoaraiosis on Noncontrast Head CT Using CT-MRI Paired Data Without Human Annotation.Brain and behavior · 2025Article
- Deep learning-based automatic segmentation of cerebral infarcts on diffusion MRI.Scientific reports · 2025Article
- Inhibition of nitric oxide synthase transforms carotid occlusion-mediated benign oligemia intoTheranostics · 2025Article
- Automated Segmentation of MRI White Matter Hyperintensities in 8421 Patients with Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2024Article
- Effect of infarct location and volume on cognitive dysfunction in elderly patients with acute insular cerebral infarction.World journal of psychiatry · 2024Article
- Ischaemic stroke despite antiplatelet therapy: Causes and outcomes.European stroke journal · 2023Article
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Authors and funding
28 authors at 11 institutions in 2 countries.
Funding
Abstract
objectiveWe investigated (1) the associations of pre-stroke aspirin use with thrombus burden, infarct volume, hemorrhagic transformation, early neurological deterioration (END), and functional outcome, and (2) whether stroke subtypes modify these associations in first-ever ischemic stroke.
methodsThis multicenter magnetic resonance imaging (MRI)-based study included 5,700 consecutive patients with acute first-ever ischemic stroke, who did not undergo intravenous thrombolysis or endovascular thrombectomy, from May 2011 through February 2014. Propensity score-based augmented inverse probability weighting was performed to estimate adjusted effects of pre-stroke aspirin use.
resultsThe mean age was 67 years (41% women), and 15.9% (n = 907) were taking aspirin before stroke. Pre-stroke aspirin use (vs nonuse) was significantly related to a reduced infarct volume (by 30%), particularly in large artery atherosclerosis stroke (by 45%). In cardioembolic stroke, pre-stroke aspirin use was associated with a ~50% lower incidence of END (adjusted difference = -5.4%, 95% confidence interval [CI] = -8.9 to -1.9). Thus, pre-stroke aspirin use was associated with ~30% higher likelihood of favorable outcome (3-month modified Rankin Scale score < 3), particularly in large artery atherosclerosis stroke and cardioembolic stroke (adjusted difference = 7.2%, 95% CI = 1.8 to 12.5 and adjusted difference = 6.4%, 95% CI = 1.7 to 11.1, respectively). Pre-stroke aspirin use (vs nonuse) was associated with 85% less frequent cerebral thrombus-related susceptibility vessel sign (SVS) in large artery atherosclerosis stroke (adjusted difference = -1.4%, 95% CI = -2.1 to -0.8, p < 0.001) and was associated with ~40% lower SVS volumes, particularly in cardioembolic stroke (adjusted difference = -0.16 cm
interpretationPre-stroke aspirin use associates with improved functional independence in patients with first-ever ischemic large arterial stroke by reducing infarct volume and/or END, likely by decreasing thrombus burden, without increased risk of hemorrhagic transformation. ANN NEUROL 2021;90:763-776.
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