ArticleEsophagus : official journal of the Japan Esophageal Society2022
Saliva secretion is reduced in mild reflux esophagitis patients.
Article in Esophagus : official journal of the Japan Esophageal Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Impact of Gastroesophageal Reflux Disease on Salivary Flow Rate, pH and Buffer Capacity: A Systematic Review and Meta-Analysis.Journal of oral rehabilitation · 2025Pooled it
- In females, salivary secretion was significantly lower in patients with severe reflux esophagitis than in healthy controls.Esophagus : official journal of the Japan Esophageal Society · 2024Article
- Among females older than 50 years, saliva secretion is significantly lower in non-erosive reflux disease patients than in healthy controls.Esophagus : official journal of the Japan Esophageal Society · 2024Article
- Characteristics of proton pump inhibitor-resistant severe reflux esophagitis and efficacy of vonoprazan in elderly (older than 75 years) and non-elderly groups.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Article
- Differences in salivary secretion and epidermal growth factor concentrations in mild reflux esophagitis and non-erosive reflux disease.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- Salivary biomarkers and esophageal disorders.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2022Review
- Determinants of reflux perception in patients with non-erosive reflux disease who have reflux-related symptoms on potassium-competitive acid blocker therapy.Esophagus : official journal of the Japan Esophageal Society · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSalivary secretion in patients with mild reflux esophagitis has not been examined. In this study, saliva secretion and salivary epidermal growth factor (EGF) in patients with mild reflux esophagitis were investigated.
methodsThirty-eight mild reflux esophagitis patients and 38 control subjects were recruited for this case-control study. Saliva secretion testing was performed. Saliva secretion was assessed as follows: each patient chewed sugar-free gum for 3 min prior to endoscopy, and the volume and pH of saliva before and after acid loading as an index of the acid-buffering capacity were measured. The salivary EGF concentration was assessed by ELISA.
resultsThe volume of saliva secreted was significantly (p = 0.0412) lower in the mild reflux esophagitis group than in the control group, with medians (25th-75th percentile) of 4.2 mL/3 min [2.6-6.2] and 6.0 [3.9-8.0], respectively. No significant differences were observed in salivary pH (the mild reflux esophagitis group: 7.1 [6.9-7.2], the control group 7.2 [7.1-7.3]). Salivary pH after acid loading was significantly (p = 0.0009) lower in the mild reflux esophagitis group (5.9 [5.5-6.3]) than in the control group (6.3 [6.2-6.5]). No significant differences were noted in salivary EGF concentrations (the mild reflux esophagitis group: 1739.0 pg/mL [1142.3-3329.0], the control group: 1678.0 [1091.8-2122.5].
conclusionThe secretion volume and acid-buffering capacity of stimulated saliva were reduced in patients with mild reflux esophagitis.
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