ReviewApplied microbiology and biotechnology2021
Marine dissolved organic matter: a vast and unexplored molecular space.
Review in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Leveraging Dissolved Organic Matter Collections as a Natural Chemical Library to Link Molecular Traits with Cellular Morphological Responses.Environmental science & technology · 2026Article
- Practical guide for marine exo-metabolomic sample preparation.The ISME journal · 2026Review
- Constraining biorecalcitrance of carboxyl-rich alicyclic molecules in the ocean.Science advances · 2025Article
- Article
- Cycling of labile and recalcitrant carboxyl-rich alicyclic molecules and carbohydrates in Baffin Bay.Nature communications · 2024Article
- Variable aging and storage of dissolved black carbon in the ocean.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Proton Binding Characteristics of Dissolved Organic Matter Extracted from the North Atlantic.Environmental science & technology · 2023Article
- Expanding the Limits of Structural Characterization of Marine Dissolved Organic Matter Using Nonuniform Sampling Frequency-Reversed Edited HSQC NMR.Analytical chemistry · 2023Article
- Constraints on microbial metabolic complexity.Nature microbiology · 2023Article
- Bioactivity profile of dissolved organic matter and its relation to molecular composition.Natural products and bioprospecting · 2023Article
- Evaluation of Data-Dependent MS/MS Acquisition Parameters for Non-Targeted Metabolomics and Molecular Networking of Environmental Samples: Focus on the Q Exactive Platform.Analytical chemistry · 2023Article
- Characterization of a Newly Available Coastal Marine Dissolved Organic Matter Reference Material (TRM-0522).Analytical chemistry · 2023Article
- Setting the geological scene for the origin of life and continuing open questions about its emergence.Frontiers in astronomy and space sciences · 2023Article
- Diving into the Molecular Diversity ofACS omega · 2022Article
- New Perspectives on the Marine Carbon Cycle-The Marine Dissolved Organic Matter Reactivity Continuum.Environmental science & technology · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Marine dissolved organic matter (DOM) comprises a vast and unexplored molecular space. Most of it resided in the oceans for thousands of years. It is among the most diverse molecular mixtures known, consisting of millions of individual compounds. More than 1 Eg of this material exists on the planet. As such, it comprises a formidable source of natural products promising significant potential for new biotechnological purposes. Great emphasis has been placed on understanding the role of DOM in biogeochemical cycles and climate attenuation, its lifespan, interaction with microorganisms, as well as its molecular composition. Yet, probing DOM bioactivities is in its infancy, largely because it is technically challenging due to the chemical complexity of the material. It is of considerable interest to develop technologies capable to better discern DOM bioactivities. Modern screening technologies are opening new avenues allowing accelerated identification of bioactivities for small molecules from natural products. These methods diminish a priori the need for laborious chemical fractionation. We examine here the application of untargeted metabolomics and multiplexed high-throughput molecular-phenotypic screening techniques that are providing first insights on previously undetectable DOM bioactivities. KEY POINTS: • Marine DOM is a vast, unexplored biotechnological resource. • Untargeted bioscreening approaches are emerging for natural product screening. • Perspectives for developing bioscreening platforms for marine DOM are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.